Recombinant human PHF1 protein
货号:
P03717
品牌:
Jinpan
产品简介
基因名 | PHF1 |
英文全称 | PHD finger protein 1 |
别称 | MTF2L2;PCL1;PHF2;TDRD19C;hPHF1 |
中文名称 | PHD指蛋白1 |
Uniprot | O43189 |
GeneID | 5252 |
交叉反应(推测) | Human Mouse (A.thaliana) |
氨基酸大小 | 38kDa |
表达氨基酸 | 218-567aa |
Background | Polycomb group (PcG) that specifically binds histone H3 trimethylated at ‘Lys-36’ (H3K36me3) and recruits the PRC2 complex.Involved in DNA damage response and is recruited at double-strand breaks (DSBs).Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex.According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci.According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2.Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53. |
Application | Immunology research |
Derived from | E.coli |
Purification | NI-NTA affinity purification |
Formulation | Lyophilized from a 0.2 μm filtered solution of Tris-HCl, PH8.0. |
Shipping | The product is shipped at -20°C temperature. Upon receipt, store it immediately at the temperature listed below. |
Storage | Reconstituted protein solution can be stored at 4-7°C for 1-2 months, stable at < -20°C for 2-3 years. |
Reconstitution | Reconstituted protein solution can be diluted with distilled PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Purity | Purity≥85% as determined by reducing SDS-PAGE. |
Endotoxin | / |
Bioactive | Unknown. (Ban’t be used in biological activity experiments such as cell culture, treatment and diagnosis.) |
规格 | 10ug 50ug 100ug 1mg |