SCH58261CAS号： 160098-96-4分子式： C18H15N7O分子量： 345.36描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)参考文献
| 产品描述 | |
| 描述 |
SCH 58261 is a potent and selective A2a adenosine receptor antagonist with Ki of 2.3 nM and 2 nM for rat A2a and bovine A2a, respectively. |
| 纯度 |
＞98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
SCH-58261；SCH 58261
|
| 外观 |
off-white solid
|
| 可溶性/溶解性 |
DMSO : 34.5 mg/mL (100 mM)
|
| 生物活性 | |
| 靶点 |
bovine A2a；rat A2a
|
| In vitro(体外研究) |
SCH 58261 causes the inhibition of rabbit platelet aggregation and porcine coronary artery relaxation by antagonizing competitively the effects induced by CGS 21680.
|
| In vivo(体内研究) |
In mice with Spinal cord injury, SCH58261 (0.01 mg/kg, i.p.) reduces demyelination and levels of TNF-α, Fas-L, PAR, Bax expression and activation of JNK MAPK. Chronic SCH58261 administration improves the neurological deficit up. In rats with 6-OHDA-induced Parkinson’s disease, SCH58261 (2 mg/kg, i.p.) improves the 6-OHDA-induced bradykinesia and motor disturbance.
|
| 参考文献 | |
| 参考文献 |
[1] Zocchi C, et al. J Pharmacol Exp Ther. 1996, 276(2), 398-404. [2] Paterniti I, et al. J Neuroinflammation. 2011, 8, 31. [3] Reyhani-Rad S, et al. Acta Cir Bras. 2016, 31(2), 133-137. |
分子结构图
