LLY-507
| 别名 | LLY507 |
| 英文名称 | LLY-507 |
| CAS | 1793053-37-8 |
| 分子式 | C22H21Cl2N5O |
| 分子量 | 574.76 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| SMILES | O=C(C1=CC(C2=CC=CC=C2N3CCN(CCN4C=C(C)C5=C4C=CC=C5)CC3)=CC(C#N)=C1)NCCCN6CCCC6 |
| 靶点 | Histone Methyltransferase |
| 规格 | 5mg 10mM*1mL (in DMSO) |
LLY-283CAS号： 2040291-27-6分子式： C17H18N4O4分子量： 342.36描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
LLY-283 is the potent and selective SAM-competitive chemical probe for PRMT5. It inhibits PRMT5 enzyme activity with IC50 of 20 nM for methylation of an H4R3 derived peptide substrate, and shows greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
LM-5179
|
| 外观 |
powder
|
| 可溶性/溶解性 |
DMSO ：68 mg/mL (198.63 mM)
|
| 生物活性 | |
| 靶点 |
PRMT5
|
| In vitro(体外研究) |
LLY-283 is a potent, oral and selective arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM in vitro and 25 nM in cells, as well as a Kd of 6 nM for PRMT5:MEP50 complex in vitro; LLY-283 inhibits the proliferation of A375 cell with an IC50 of 46 nM.
|
| In vivo(体内研究) |
LLY-283 (20 mg/kg; p.o., QD (once a day)) causes a significant inhibition on tumor growth in mice bearing A375 cells after treatment for 28 days.
|
分子结构图
LLY-283
| 别名 | 2-(4-Aminopyrrolo[2,3-d]pyrimidin-7-yl)-5-[hydroxy(phenyl)methyl]oxolane-3,4-diol |
| CAS | 2040291-27-6 |
| 分子式 | C17H18N4O4 |
| 分子量 | 342.35 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| SMILES | O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC=CC=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3 |
| 靶点 | Histone Methyltransferase;PRMT5 |
| 规格 | 5mg |