GGTI-286CAS号: 171744-11-9分子式: C23H31N3O3S • 2CF3COOH分子量: 657.6描述纯度储存/保存方法别名外观可溶性/溶解性
产品描述 | |
描述 |
GGTI 286 is an inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively). It also inhibits geranylgeranylation of oncogenic K-Ras4B in NIH3T3 cells (IC50 = 2 μM) and blocks K-Ras4B-induced activation of MAP kinase (IC50 = 1 μM). GGTI 286 (2.5-50 μM) is cytotoxic to RPMI-8226, H929, and U266 multiple myeloma cells in a concentration-dependent manner. It also reduces angiotensin II-induced collagen mRNA and protein production in rat cardiac fibroblasts. |
纯度 |
≥90%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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基本信息 | |
别名 |
GGTI 286 (trifluoroacetate salt)
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外观 |
Glassy solid
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可溶性/溶解性 |
Soluble in DMSO
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分子结构图