GGTI-286

GGTI-286CAS号: 171744-11-9分子式: C23H31N3O3S • 2CF3COOH分子量: 657.6描述纯度储存/保存方法别名外观可溶性/溶解性

产品描述
描述

GGTI 286 is an inhibitor of geranylgeranyltransferase I (GGTase I) that selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells (IC50s = 2 and >30 μM, respectively). It also inhibits geranylgeranylation of oncogenic K-Ras4B in NIH3T3 cells (IC50 = 2 μM) and blocks K-Ras4B-induced activation of MAP kinase (IC50 = 1 μM). GGTI 286 (2.5-50 μM) is cytotoxic to RPMI-8226, H929, and U266 multiple myeloma cells in a concentration-dependent manner. It also reduces angiotensin II-induced collagen mRNA and protein production in rat cardiac fibroblasts.

纯度
≥90%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
别名
GGTI 286 (trifluoroacetate salt)
外观
Glassy solid
可溶性/溶解性
Soluble in DMSO

分子结构图

GGTI-286