CZC-54252 Hydrochloride

CZC-54252 HydrochlorideCAS号: 1784253-05-9分子式: C22H26Cl2N6O4S分子量: 541.45描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)

产品描述
描述
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human neuronal injury with an EC50 of 1 nM.
纯度
98%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
DMSO:30 mg/mL (55.41 mM)
生物活性
靶点
G2019S LRRK2:1.85 nM (IC50), Wild-type LRRK2:1.28 nM (IC50)
In vitro(体外研究)
CZC-54252 hydrochloride(1.6 nM) fully reverses G2019S LRRK2-induced human neuronal injury to wild-type levels. CZC-54252 hydrochloride inhibits the recombinant human wild-type LRRK2 with an IC50 ranging from 1 to 5 nM. CZC-54252 hydrochloride inhibits the G2019S mutant with an IC50 ranging from 2 to 7 nM in a TF-FRET assay[2].