Dor-02/10/50-Dorsomorphin,Dor-02/10/50-小分子化合物

产品名称:Dorsomorphin
产品编号:Dor-02/10/50
品牌;StemRD
厂家:StemRD
产品规格:2/10/50mg
储存条件:-80℃
到货时间:2-5天

产品信息

TGF-β家族成员广泛存在于从果蝇到人多种生物的 各种组织中,对正常细胞、癌变细胞都有着显著作用。TGF-β除了影响细胞的增殖、分化,还在胚胎发育、胞外基质形成、 骨的形成和重建等方面起着重要作用。

Dorsomorphin:
A selective inhibitor of bone morphogenetic protein (BMP) type I receptors (ALK-2, ALK-3 and ALK-6). Also inhibits AMP-activated protein kinase (AMPK). 6-[4-(2-PIPERIDIN-1-YLETHOXY)PHENYL]-3-PYRIDIN-4-YLPYRAZOLO[1,5-A]PYRIMIDINE

Ref: Yu et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat. Chem. Biol. 4 33, 2008.

Purity:
Greater than 98% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
Not determined.