产品名称：NT-3 神经生长因子
产品编号：NT-010/050/250
品牌；StemRD
厂家：StemRD
产品规格：10/50/250ug
储存条件：-80℃
到货时间：2-5天

产品信息

Neurotrophin-3 (NT-3) is a member of the NGF family of neurotrophic factors that also include NGF, BDNF and NT-4/5. These secreted neurotrophins are processed proteolytically from a disulfide-containing precursor. The mature and bio-active form of NT-3 is a noncovalentlylinked homodimer of two 13.6kDa identical subunits. StemRD's NT-3is made in human 293 cells which renders natural dimerization and human-specific post-translational modifications. We purified this product through a series of chromatography including HPLC to near homogeneity.

Purity:
Greater than 95% by SDS-PAGE under reducing conditions and visualized by silver staining.

Biological Activity
The activity was determined by using a NFAT luciferase reporter gene assay in 293 cells cotransfected with TrkC receptor (Wang, et al., Cellular Assays for High-Throughput Screening for Modulators of Trk Receptor Tyrosine Kinases. Curr Chem Genomics. 2008; 1: 27–33). The EC50 ranges from0.5 – 5.0 ng/ml