RSPOFC-025-R-spondin-1 Fc fusion, human 25µg WNT信号通路增强剂-细胞重编程

R-spondin-1 Fc fusion, human 25µg WNT信号通路增强剂
英文名称: R-spondin-1 Fc fusion, human
产品应用: WNT/β-catenin信号通路增强剂
中国俗称: WNT信号通路增强剂 中国简称: WNT信号通路增强剂
注册品牌: StemRD 生产厂家: 美国StemRD公司
订购货号: RSPOFC-025
规格型号: 25µg
保存温度: ﹣20℃
产品种类: 信号通路调控剂
到货时间: 1~5天

R-spondin-1 Fc fusion, human 25µg WNT信号通路增强剂
英文名称:  R-spondin-1 Fc fusion, human
产品应用:  WNT/β-catenin信号通路增强剂
中国俗称:  WNT信号通路增强剂  中国简称:  WNT信号通路增强剂
注册品牌:  StemRD  生产厂家:  美国StemRD公司
订购货号:  RSPOFC-025
规格型号:  25µg
保存温度:  ﹣20℃
产品种类:  信号通路调控剂
到货时间:  1~5天

产品英文名称:R-spondin-1 Fc fusion, human
产品中文名称:人重组R-spondin-1 Fc fusion蛋白

R-spondin-1 Fc fusion, human产品介绍:
R-spondin-1是权威WNT信号通路的天然增强剂。当与激活β-catenin信号通路的WNT蛋白联合使用时,R-spondin-1能通过与LGR5和LGR4融合而有效提高权威WNT蛋白的活性。
向小鼠注射重组R-spondin-1蛋白可以激活β-catenin信号通路和肠道下皮细胞的增殖,为临床改善化疗诱导结肠炎操作提供了基础和依据。
本产品是全片段R-spondin-1与人IgG1细胞Fc片段的C-终端相融合而得到的。这种融合保证了体内外蛋白的稳定性而不影响其生物活性。 StemRD公司的R-spondin-1 Fc融合蛋白是由人293细胞作为分泌蛋白,并经过一系列的色谱分析法纯化而得到。

R-spondin-1 Fc fusion, human产品英文简述:
R-spondin-1 is a natural enhancer of the canonical WNT pathway. When used together with WNT proteins that activate the beta-catenin pathway, Rspondin- 1 enhances the activity of canonical WNT proteins by binding to LGR5 and LGR4 (refs.) Injection of recombinant R-Spondin-1 into mouse causes activation of the-catenin pathway and proliferation of intestinal crypt cells, which forms the basis for a clinical trial in amelioration of chemotherapy-induced colitis.
This product is the full-length R-Spondin-1 fused at its C-terminus to the Fc domain of human IgG1. This fusion increases the stability of the protein in vitro and in vivo without compromising its biological activity. StemRD’s R-Spondin-1 Fc fusion protein is produced in human 293 cells as a secreted protein and purified by protein A chromatography.

• Purity: Greater than 90% as determined by SDS-PAGE analysis
• Biological Activity: The activity was determined by using a TCF reporter gene assay in cultured
human cells. The EC50 ranges from 5 – 20 ng/ml in the presence of 10ng/mL human WNT-3a. Activity in other assays should be determined by each individual setting.
• For Research Use Only. Not for Use in Human

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