InvivoGentlrl-mdpMDP
InvivoGentlrl-bmdpMDP Biotin
InvivoGentlrl-mdpcMDP control
InvivoGentlrl-fmdpMDP FITC
InvivoGentlrl-rmdpMDP Rhodamine
InvivoGentlrl-metfMetformin

InvivoGen tlrl-fmdp MDP FITC
MDP FITC

FITC-labeled MDP

Muramyl dipeptide (MDP) is the minimal bioactive peptidoglycan motif common to all bacteria, the essential structure required for adjuvant activity in vaccines. MDP has been shown to be recognized by NOD2, but not TLR2, nor TLR2/1 or TLR2/6 associations [1,2]. This recognition is highly stereospecific of the L-D isomer, excluding any reaction to the D-D or L-L analogs [2]. The potent adjuvant activity of MDP may also be linked to an activation of the CIAS1/NALP3/Cryopyrin inflammasome [3].

MDP FITC is coupled via a 6-aminohexanoic acid spacer molecule at the C6 position of the muric acid. This spacer linker arm minimizes potential steric hindrance effects.

Specificity: NOD2 agonist
Working concentration: 100 ng -10 μg/ml
Endotoxin level: EndoFit™ (<0.001 EU/μg)
Solubility: DMSO (10 mg/ml)
Molecular weight: 995.02

Spectral Properties of FITC
Excitation λ max: 495 nm
Emission λ max: 525 nm

Contents

• 500 μg Muramyl dipeptide (MDP) labeled with FITC
 • 2 ml sterile endotoxin-free water

MDP FITC is provided as a lyophilized powder and shipped at room temperature. Store at -20°C. Upon resuspension, aliquote MDP FITC and store at -20°C. Product is stable 6 months at -20°C when properly stored. Avoid repeated freeze-thaw cycles.

Ref.

1. Girardin SE. et al., 2003. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem. 278(11):8869-72.
2. Inohara N. et al., 2003. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease.J Biol Chem. 278(8):5509-12.
3. Martinon F. et al., 2004. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol. 14(21):1929-34.

MDP FITC

InvivoGen tlrl-mdpc MDP control 5 mg
InvivoGen tlrl-fmdp MDP FITC 500 µg
InvivoGen tlrl-rmdp MDP Rhodamine 500 µg
InvivoGen tlrl-metf Metformin 1 g
InvivoGen tlrl-mg132 MG-132 5 mg
InvivoGen rtp-mmda5 Mouse MDA-5 RT-Primers 2 x 2.5 nmol
InvivoGen rtp-mnod1 Mouse NOD1 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mnod2 Mouse NOD2 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mrigi Mouse RIG-I RT-Primers 2 x 2.5 nmol
InvivoGen rtp-mtlr1 Mouse TLR1 RT-Primer pair 2 x 2.5 nmol
InvivoGen tlrl-kit1mw Mouse TLR1-9 Agonist kit (9 ligands) 1 kit
InvivoGen rts-mtlrs Mouse TLR1-9 RT-Primer Set 20 x 2.5 nmol
InvivoGen rtp-mtlr2 Mouse TLR2 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mtlr3 Mouse TLR3 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mtlr4 Mouse TLR4 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mtlr5 Mouse TLR5 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mtlr6 Mouse TLR6 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mtlr7 Mouse TLR7 RT-Primer pair 2 x 2.5 nmol
InvivoGen rtp-mtlr8 Mouse TLR8 RT-Primer pair 2 x 2.5 nmol
InvivoGen tlrl-kit9m Mouse TLR9 Agonist Kit 1 kit
InvivoGen rtp-mtlr9 Mouse TLR9 RT-Primer pair 2 x 2.5 nmol
InvivoGen tlrl-mpls MPLAs 1 mg
InvivoGen vac-mpls MPLAs Vaccigrade™ 1 mg
InvivoGen tlrl-mpla MPLA-SM 1 mg
InvivoGen vac-mpla MPLA-SM VacciGrade™ 1 mg
InvivoGen tlrl-msu MSU Crystals 5 mg
InvivoGen tlrl-mtd M-TriDAP 1 mg
InvivoGen tlrl-mtl M-TriLYS 1 mg
InvivoGen tlrl-mtn M-TriLYS-D-ASN 1 mg
InvivoGen tlrl-arr Multi-TLR Array™ 1 plate
InvivoGen tlrl-arr-5 Multi-TLR Array™ 5 plates
InvivoGen tlrl-mbt Murabutide 5 mg
InvivoGen tlrl-mbtc Murabutide control 5 mg
InvivoGen tlrl-sio Nano-SiO2 10 mg
InvivoGen tlrl-gmdp N-Glycolyl-MDP 5 mg
InvivoGen vac-gmdp N-Glycolyl-MDP VacciGrade 5 mg
InvivoGen tlrl-nig Nigericin 10 mg
InvivoGen tlrl-nig-5 Nigericin 50 mg
InvivoGen tlrs-nod1 NOD1 Test Strip 2 x 6 strips
InvivoGen tlrs-nod1-5 NOD1 Test Strip 10 x 6 strips
InvivoGen tlrl-nodkit2 NOD1/2 Agonist Kit (10 ligands) 1 kit
InvivoGen tlrs-nod2 NOD2 Test Strip 2 x 6 strips
InvivoGen tlrs-nod2-5 NOD2 Test Strip 10 x 6 strips
InvivoGen ant-nr-1 Normocin™ 500 mg (10 x 1 ml)
InvivoGen ant-nr-2 Normocin™ 1 g (1 x 20 ml)
InvivoGen tlrl-1585 ODN 1585 200 µg
InvivoGen tlrl-1585-1 ODN 1585 1 mg
InvivoGen tlrl-1585-5 ODN 1585 5 mg
InvivoGen tlrl-1585c ODN 1585 control 200 µg
InvivoGen tlrl-1585c-1 ODN 1585 control 1 mg
InvivoGen tlrl-1585c-5 ODN 1585 control 5 mg
InvivoGen tlrl-1585f ODN 1585 FITC 50 µg
InvivoGen vac-1585-1 ODN 1585 VacciGrade 1 mg
InvivoGen tlrl-1668 ODN 1668 200 µg
InvivoGen tlrl-1668-1 ODN 1668 1 mg
InvivoGen tlrl-1668-5 ODN 1668 5 mg
InvivoGen tlrl-1668c ODN 1668 control 200 µg
InvivoGen tlrl-1668c-1 ODN 1668 control 1 mg
InvivoGen tlrl-1668c-5 ODN 1668 control 5 mg
InvivoGen tlrl-1668f ODN 1668 FITC 50 µg
InvivoGen tlrl-1826 ODN 1826 200 µg
InvivoGen tlrl-1826-1 ODN 1826 1 mg
InvivoGen tlrl-1826-5 ODN 1826 5 mg
InvivoGen tlrl-1826b ODN 1826 Biotin 50 µg
InvivoGen tlrl-1826c ODN 1826 control (ODN 2138) 200 µg
InvivoGen tlrl-1826c-1 ODN 1826 control (ODN 2138) 1 mg
InvivoGen tlrl-1826c-5 ODN 1826 control (ODN 2138) 5 mg
InvivoGen tlrl-1826f ODN 1826 FITC 50 µg

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