OKT3单克隆抗体的特异性反应的CD3 / T淋巴细胞抗原受体复合物的ε链。CD3复合物含有γ，δ，和ε链，和它的TCR复杂的部分，由所有成熟T淋巴细胞和胸腺细胞系的表达。CD3增强的信号转导的抗原识别。
OKT3抗体是一种免疫抑制，这已被证明是一种有效的治疗剂，肝，心，肾移植排斥反应。
Catalogue Number : 05121-77
Description
The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and renal allograft rejection.
CD3产品描述：OKT3单克隆抗体的特异性反应的CD3 / T淋巴细胞抗原受体复合物的ε链。CD3复合物含有γ，δ，和ε链，和它的TCR复杂的部分，由所有成熟T淋巴细胞和胸腺细胞系的表达。CD3增强的信号转导的抗原识别。
PeproTech公司的BioGems产品OKT3抗体是一种免疫抑制，这已被证明是一种有效的治疗剂，肝，心，肾移植排斥反应。
Additional Information
Clone
OKT3
Format:
PE-Cy7
Applications
FC
Reactivity
Human
Isotype:
Mouse IgG2a, kappa
Research Interest: Adaptive Immunity
Cell Type: Treg cells, T Cells, NK and NKT Cells, Th17 cells
Preperation:
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation:
Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References:
Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
Knapp W (1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., … & Jolliffe, L. K. (1994). Humanization of the murine anti-human CD3 monoclonal antibody OKT3. Human Antibodies, 5(1), 41-47.
Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., … & A’t Hart, B. (2009). A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. Journal of Histochemistry & Cytochemistry, 57(12), 1159-1167.
Anti-Human CD3 PE-Cy7
Technical Data Sheet
Catalogue Number : 05121-77
RUO: For Research Use Only. Not for use in diagnostic procedures.
Product Information
Clone: OKT3
Format/Conjugate: PE-Cy7
Concentration: 5 uL (0.5 ug)/test
Reactivity: Human
Laser: Blue (488nm)
Peak Emission: 785nm
Peak Excitation: 496nm
Filter: 780/60
Brightness (1=dim,5=brightest): 4
Isotype: Mouse IgG2a, kappa
Formulation: Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Storage: Product should be kept at 2-8°C and protected from prolonged exposure to light.
Applications: FC
Description
The OKT3 monoclonal antibody specifically reacts with the ε chain of the CD3/T lymphocyte antigen receptor complex. The
CD3 complex contains γ, δ, and ε chains, and it is part of the TCR complex, expressed by all mature T lymphocytes and
by the thymocyte lineage. CD3 enhances the antigen recognition by signal transduction.
The OKT3 antibody is an immunosuppressive, which has proven to be an effective therapeutic agent in liver, heart, and
renal allograft rejection.
Preparation & Storage
The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Application Notes
The antibody has been analyzed for quality through the flow cytometric analysis of the relevant cell type. The antibody
can be used at less than or equal to 5 μL per test. A test is the amount of antibody required to stain a cell sample in
the final volume of 100 μL.
代理的PeproTech公司旗下的BioGems产品，咨询：
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References
1.Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York
2.
Knapp W;(1989) Leucocyte typing IV: white cell differentiation antigens. Oxford University Press, 1989.
3.
Adair, J. R., Athwal, D. S., Bodmer, M. W., Bright, S. M., Collins, A. M., Pulito, V. L., … ; Jolliffe, L. K. (1994). Humanization of the murine
anti-human CD3 monoclonal antibody OKT3.;Human Antibodies,;5(1), 41-47.
4.
Kap, Y. S., van Meurs, M., van Driel, N., Koopman, G., Melief, M. J., Brok, H. P., … ; A’t Hart, B. (2009). A monoclonal antibody selection for
immunohistochemical examination of lymphoid tissues from non-human primates.;Journal of Histochemistry ; Cytochemistry,;57(12), 1159-1167.
PeproTech公司旗下的BioGems产品的其他相关信息如下：
Additional OKT3 Formats
Cat.No. Format Starting From
货号：05121-20 Purified
货号：05121-25 SAFIRE Purified
货号：05121-40 BG Violet 450
货号：05121-60 PE
货号：05121-80 APC
货号：05121-50 FITC
货号：05121-70 PerCP-Cy5.5
货号：05121-77 PE-Cy7
