Azaguanine-8 is a purine analogs showing antineoplastic activity by competing with guanine in the metabolism. 8-Azaguanine is a purine analogue that shows antineoplastic activity. Azaguanine-8 functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, so that it can inhibite cellular growth. Azaguanine-8 has been reported that a study of the in vivo metabolism of 8-azaguanine-2-C 14 by mouse neoplasms that are susceptible or resistant to growth inhibition by 8-azagnanine. The results show that the growth of those neoplasms which convert significant amounts of 8-azaguanine to 8-azaguanylic acid is inhibited by 8-azaguanine.

>98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

8-氮鸟嘌呤

白色粉末

DMSO ：6 mg/mL (39.44 mM)

Purine nucleoside phosphorylase

8-Azaguanine is a purine analogue that shows antineoplastic activity. It functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.

A study of the in vivo metabolism of 8-azaguanine-2-C 14 by mouse neoplasms that are susceptible or resistant to growth inhibition by 8-azagnanine have been reported. The results show that the growth of those neoplasms which convert significant amounts of 8-azaguanine to 8-azaguanylic acid is inhibited by 8-azaguanine.

CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture.
Dourado M,et al. Pathophysiology. 2007 May;14(1):3-10. PMID:

分子结构图