7-Chlorokynurenic acidCAS号： 18000-24-3分子式： C10H6CINO3分子量： 223.62描述应用纯度储存/保存方法形态别名外观IC50PK值Ki 数据可溶性/溶解性EC号码靶点In vivo(体内研究)
| 产品描述 | |
| 描述 |
7-Chlorokynurenic acid (7-CKA) is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor (IC50=0.56 μM). 7-Chlorokynurenic acid is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a Ki of 0.59 μM. 7-Chlorokynurenic acid has potent antinociceptive actions after neuraxial delivery.
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| 应用 |
An NMDA receptor antagonist and inhibitor of EAAT
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 形态 |
Solid
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| 基本信息 | |
| 别名 |
7-氯犬尿酸；7-氯-4-羟基喹啉-2-羧酸; 7-Chloro-4-hydroxyquinoline-2-carboxylic acid；7-CKA
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| 外观 |
Off-white Solid
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| IC50 |
Glutamate NMDA receptor: IC50 = 320 nM (rat); Glutamate [NMDA] receptor subunit 3B: IC50 = 8 µM (rat)
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| PK值 |
pKa: 0.90 (Predicted), pKb: 9.79 (Predicted)
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| Ki 数据 |
Vesicular glutamate transporter 3: Ki= 590 µM (rat)
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| 可溶性/溶解性 |
DMSO : 16.67 mg/mL (74.55 mM; Need ultrasonic)
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| EC号码 |
241-913-6
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| 生物活性 | |
| 靶点 |
N-methyl-D-aspartate receptor
reuptake of glutamate |
| In vivo(体内研究) |
Male Sprague-Dawley rats pretreated with 7-Chlorokynurenic acid (10 nM) shows a significant retardation of development of both the electroencephalographic and motor (17.7±2.9 daily stimulations) components of the seizure response.
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分子结构图
