SCH-772984CAS号： 942183-80-4分子式： C33H33N9O2分子量： 587.67描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively. |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
SCH 772984; SCH772984
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO ：10 mg/mL (17 mM) warmed
|
| 生物活性 | |
| 靶点 |
ERK2 ,ERK1
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| In vitro(体外研究) |
SCH772984 is a novel, selective and ATP competitive inhibitor of ERK1/2. SCH772984 inhibits phosphorylation of the ERK substrate p90 ribosomal S6 kinase (T359/S363 phospho-RSK) in a dose-dependent manner. SCH772984 also inhibits phosphorylation of residues in the activationloop of ERK itself. SCH772984 demonstrates EC50 values
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| In vivo(体内研究) |
SCH772984 induces tumor regressions in xenograft models at tolerated doses. SCH772984 effectively inhibites MAPK signaling and cell proliferation in BRAF or MEK inhibitor resistant models.
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分子结构图
