BMS-929075CAS号： 1217338-97-0分子式： C31H24F2N4O3分子量： 538.54描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:27.5 mg/mL (51.06 mM)
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| 生物活性 | |
| 靶点 |
HepG2:>12.5 µM(CC50), Huh-7:60 µM(CC50)
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| In vitro(体外研究) |
BMS-929075 (0-60 µM) showed cytotoxicity with CC50 values of 60, >12.5, and >50 µM for Huh-7, HepG2, and primary human hepatocytes, respectively.[1]
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| In vivo(体内研究) |
BMS-929075 (i.v. 2 mg/kg; orally 6 mg/kg) showed good pharmacokinetic parameters with an oral bioavailability of 48% in rats.[1]
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