JNJ-37822681

JNJ-37822681CAS号: 935776-74-2分子式: C17H17F5N4分子量: 372.34描述纯度储存/保存方法可溶性/溶解性靶点In vivo(体内研究)

产品描述
描述
JNJ-37822681 is a novel, highly selective dopamine D₂ receptor antagonist characterized by a rapid dissociation rate from the dopamine D₂ receptor.
纯度
98%
储存/保存方法
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性
DMSO:55 mg/ml (147.71 mM)
生物活性
靶点
D2:0.39 mg/kg(ED50)
In vivo(体内研究)
JNJ-37822681 occupied D2 receptors in rat brain at relatively low doses (ED50 = 0.39 mg/kg) and was effective in animal models of psychosis (e.g., inhibition of apomorphine-induced stereotypy or D-amphetamine/phencyclidine-induced hyperlocomotion)[4].