2614W94CAS号： 205187-35-5分子式： C15H11F3O4S分子量： 344.31描述纯度储存/保存方法可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
2614W94 is a selective inhibitor of MAO-A with IC50 of 5 nM and Ki of 1.6 nM.
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| 纯度 |
98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 可溶性/溶解性 |
DMSO:45 mg/mL (130.7 mM)
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| 生物活性 | |
| 靶点 |
Monoamine Oxidase:(ki)1.6 nM, Monoamine Oxidase:5 nM
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| In vitro(体外研究) |
2614W94 (30 nM) shows no inhibition of MAO-B[1].
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| In vivo(体内研究) |
In rats, 2614W94 (5 mg/kg, p.o.) selectively inhibits MAO-A in brains and livers and elevates neurotransmitter amines in brain, inparticular serotonin and norepinephrine, with a redcution of their oxidized metabolites. 2614W94 (0.5, 1, 2 mg/kg, p.o.) dose-dependently potentiates 5-hydroxytryptophan-induced head twitches with an extrapolated ED50 of 1.1 mg/kg[1].
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