CGH 2466 is an Adenosine A1-R, Adenosine A2B-R and Adenosine A3-R antagonist (IC₅₀ values are 19, 21, and 80 nM respectively). CGH 2466 also inhibits p38 MAPK (IC₅₀ = 187-400 nM) and PDE4 (phosphodiesterase type 4D) (IC₅₀ = 22 nM).

An Adenosine A1-R, Adenosine A2B-R, Adenosine A3-R, and p38 inhibitor

>99%

Desiccate at 4° C

Solid

4-(3,4-Dichlorophenyl)-5-(4-pyridin yl)-2-thiazolamine dihydrochloride

n²⁰_D 1.68 (Predicted)

Adenosine A1-R: IC₅₀ = 19 nM; Adenosine A2B-R : IC₅₀ = 21 nM; PDE4D: IC₅₀ = 22 nM; Adenosine A3-R: IC₅₀ = 80 nM; p38: IC₅₀ = 187 – 400 nM

Soluble in DMSO (10 mM), and ethanol (5 mM).

MFCD08703116

5282339