ML-239CAS号： 1378872-36-6分子式： C13H10Cl3N3O2分子量： 346.6描述纯度储存/保存方法别名外观可溶性/溶解性In vitro(体外研究)参考文献
| 产品描述 | |
| 描述 |
ML239 is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM.
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| 纯度 |
≥98%
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| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 别名 |
CID-49843203；ML 239
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| 外观 |
white to beige powder
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| 可溶性/溶解性 |
DMSO : ≥ 300 mg/mL (865.55 mM)
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| 生物活性 | |
| In vitro(体外研究) |
ML239 (Compound 7j) is a potent and selective inhibitor of breast cancer stem cells, with an IC50 of 1.16 μM, with 24-fold selectivity against the control cell line. ML239 inhibits breast cancer stem-like cells, most likely through activation of fatty acid desaturase 2 (FADS2). ML239 is cytotoxic to NCIH661 cells, and FADS2 knockdown reduces ML239 cytotoxicity, and furthermore, FADS2 inhibitor SC-26196 also reduces ML239 cytotoxicity in cancer cell lines (CCLs)
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| 参考文献 | |
| 参考文献 |
1.Carmody, L.C.,Germain, A.R.,VerPlank, L., et al. Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. Journal of Biomolecular Screening 17(9), 1204-1210 (2012).
2.Germain, A.R.,Carmody, L.C.,Morgan, B., et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. Bioorganic & Medicinal Chemistry Letters 22(10), 3571-3574 (2012). 3.Carmody, L.,Garmain, A.,Morgan, B., et al. Identification of a selective small-molecule inhibitor of breast cancer stem cells – Probe 1. 1, 1-13 (2011). |
分子结构图
