SC-236 is a highly selective and potent inhibitor of Cox-2 (IC₅₀ of 10 nM) which also inhibits Cox-1 (IC₅₀ of 17.8 μM) and has antitumor properties. SC-236 exhibits longer half-life time and reduced gastric toxicity in the fasting rat model. SC-236 has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. SC-236 exhibits a potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.

98%

Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.

Solid

SC 236；SC58236

white to off-white crystalline powder

1.54 g/cm³ (Predicted)

146-148° C

543.41° C at 760 mmHg (Predicted)

n²⁰_D 1.63 (Predicted)

COX-2: IC₅₀ = 0.45 nM (human); COX-1: IC₅₀ = 17.8 µM (human)

pK_a: 9.66

Soluble in DMSO (> 20 mg/ml), methanol, and ethanol (100 mM).

MFCD00941297