Mouse anti-Phospho-PLM(S68) Monoclonal Antibody(41AT858.235)描述别名宿主特异性反应种属应用分子量类型克隆号同种型储存/保存方法存储溶液研究领域背景说明细胞定位UniProt参考文献
| 概述 | |
| 描述 |
Purified Mouse Monoclonal Antibody (Mab)
|
| 别名 |
PLM抗体;Phospholemman; FXYD domain-containing ion transport regulator 1; Fxyd1; Plm
|
| 宿主 |
Mouse
|
| 特异性 |
This PLM Antibody is generated from mice immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S68 of human PLM.
|
| 反应种属 |
Mouse
|
| 应用 |
WB~~1:100~500
|
| 分子量 |
Predicted molecular weight: 10kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 性能 | |
| 类型 |
Monoclonal Antibody
|
| 克隆号 |
41AT858.235
|
| 同种型 |
Mouse IgG1
|
| 储存/保存方法 |
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
|
| 存储溶液 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
|
| 研究领域 |
Cardiovascular;Signal Transduction;Phospho Antibodies
|
| 靶标 | |
| 背景说明 |
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed (By similarity).
|
| 细胞定位 |
Membrane; Single-pass type I membrane protein
|
| UniProt |
Q9Z239
|
| 参考文献 | |
| 参考文献 |
Phospholemman and beta-adrenergic stimulation in the heart. Wang J, et al. Am J Physiol Heart Circ Physiol, 2010 Mar. PMID 20008271.
Extracellular potassium dependence of the Na+-K+-ATPase in cardiac myocytes: isoform specificity and effect of phospholemman. Han F, et al. Am J Physiol Cell Physiol, 2009 Sep. PMID 19570895. FXYD1, a modulator of Na,K-ATPase activity, facilitates female sexual development by maintaining gonadotrophin-releasing hormone neuronal excitability. Garcia-Rudaz C, et al. J Neuroendocrinol, 2009 Feb. PMID 19187398. Cell volume control in phospholemman (PLM) knockout mice: do cardiac myocytes demonstrate a regulatory volume decrease and is this influenced by deletion of PLM? Bell JR, et al. Exp Physiol, 2009 Mar. PMID 19074587. Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase. Song J, et al. Am J Physiol Heart Circ Physiol, 2008 Oct. PMID 18708446. |
实验结果图
Western blot analysis of anti-PLM Mab (Cat. #JP100013) in 293 cells transfected with a plasmid encoding PLM.