Mouse anti-NOTCH3 Monoclonal Antibody(C-term Q2306)(487CT6.9.2)描述别名宿主特异性反应种属应用分子量类型克隆号同种型储存/保存方法存储溶液研究领域背景说明细胞定位UniProt参考文献
| 概述 | |
| 描述 |
Mouse Monoclonal Antibody (Mab)
|
| 别名 |
NOTCH3抗体;Neurogenic locus notch homolog protein 3; Notch 3; Notch 3 extracellular truncation; Notch 3 intracellular domain; NOTCH3
|
| 宿主 |
Mouse
|
| 特异性 |
This NOTCH3 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 2291-2321 amino acids from the C-terminal region of human NOTCH3.
|
| 反应种属 |
Human
|
| 应用 |
WB~~1:100~250
|
| 分子量 |
Predicted molecular weight: 244kD
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| 性能 | |
| 类型 |
Monoclonal Antibody
|
| 克隆号 |
487CT6.9.2
|
| 同种型 |
IgG1
|
| 储存/保存方法 |
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
|
| 存储溶液 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
|
| 研究领域 |
Cardiovascular;Neuroscience;Signal Transduction
|
| 靶标 | |
| 背景说明 |
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
|
| 细胞定位 |
Cell membrane; Single-pass type I membrane protein
|
| UniProt |
Q9UM47
|
| 参考文献 | |
| 参考文献 |
Liu, H., et al. Circ. Res. 107(7):860-870(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Menon, S., et al. Cephalalgia (2010) In press : Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) : |
实验结果图
NOTCH3 Antibody (Q2306) (Cat. #JP100236) western blot analysis in Hela cell line lysates (35μg/lane).This demonstrates the NOTCH3 antibody detected the NOTCH3 protein (arrow).