GO-203CAS号： 1222186-26-6分子式： C87H170N52O19S2.C2HF3O2分子量： 2426.77描述纯度储存/保存方法外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
GO-203 is a D-amino acid cell-penetrating peptide inhibitor of MUC1-C dimerization and thereby its oncogenic function. |
| 纯度 |
98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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| 基本信息 | |
| 外观 |
powder
|
| 可溶性/溶解性 |
10 mM in DMSO
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| 生物活性 | |
| 靶点 |
MUC-1C
|
| In vitro(体外研究) |
GO-203 inhibits MUC1-C homodimerization which blocks its oncogenic function. Treatment of MUC1-overexpressing SKCO-1 and Colo-205 colon cancer cells with GO-203 is associated with downregulation of the TP53-inducible glycolysis and apoptosis regulator (TIGAR) protein. GO-203 regulates AKT-S6K1-elF4A signaling in colorectal cancer cells. Targeting MUC1-C with GO-203 inhibits p-AKT in colorectal cancer cells. GO-203 treatment also results in increases in reactive oxygen species (ROS) and loss of mitochondrial transmembrane potential.
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| In vivo(体内研究) |
GO-203 is effective in inhibiting growth and survival of MUC1-positive colorectal cancer cells in mouse xenograft models. It is also effective in xenografts models of breast, prostate, lung and certain hematologic malignancy.
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分子结构图
