Gossypol (acetic acid) 醋酸棉酚

Gossypol (acetic acid) 醋酸棉酚

货号:
IG0430

品牌:
Jinpan

Gossypol (acetic acid)  醋酸棉酚

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产品简介
MDL MFCD00058385
EC EINECS 623-939-3
别名 棉子酚乙酸酯
CAS 12542-36-8
分子式 C32H34O10
分子量 578.61
纯度 HPLC≥98%
单位
生物活性 Gossypol Acetate (Pogosin, AT101; BL-193; AT-101) is a naturally occuring polyphenolic aldehyde with potential anticancer activity. It inhibit Bcl-xL and Bcl-2 proteins with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively. It also acts as an inhibitor for various dehydrogenase enzymes. Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro.[1]
SMILES OC1=C(C2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C(C(C)C)C(O)=C(O)C(C=O)=C41.O=C(O)C
靶点 Bcl-2 Family
数据来源文献 [1] Aquat Toxicol. 2000 Jun 1;49(3):181-187; Oncol Rep. 2013 Aug;30(2):731-8.
规格 5mg 10mg 10mM*1mL (in DMSO)

是多酚醛,可渗透细胞,是一些脱氢酶(如乳酸脱氢酶、NAD-linked enzymes)的抑制剂。