Gossypol (acetic acid) 醋酸棉酚
货号:
IG0430
品牌:
Jinpan
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产品简介
MDL | MFCD00058385 |
EC | EINECS 623-939-3 |
别名 | 棉子酚乙酸酯 |
CAS | 12542-36-8 |
分子式 | C32H34O10 |
分子量 | 578.61 |
纯度 | HPLC≥98% |
单位 | 瓶 |
生物活性 | Gossypol Acetate (Pogosin, AT101; BL-193; AT-101) is a naturally occuring polyphenolic aldehyde with potential anticancer activity. It inhibit Bcl-xL and Bcl-2 proteins with Kis of 0.5-0.6 μM and 0.2-0.3 mM, respectively. It also acts as an inhibitor for various dehydrogenase enzymes. Gossypol, a known antispermatogenic agent from the cotton plant genus Gossypium, was found to inhibit yellow perch sperm motility in vitro and lactate dehydrogenase activity in spermatozoa when used in a dose-dependent manner. Gossypol has been approved to have antiproliferative and apoptosis-inducing effects on some kinds of cancer cell lines in vitro.[1] |
SMILES | OC1=C(C2=C(O)C(C(C=O)=C(O)C(O)=C3C(C)C)=C3C=C2C)C(C)=CC4=C(C(C)C)C(O)=C(O)C(C=O)=C41.O=C(O)C |
靶点 | Bcl-2 Family |
数据来源文献 | [1] Aquat Toxicol. 2000 Jun 1;49(3):181-187; Oncol Rep. 2013 Aug;30(2):731-8. |
规格 | 5mg 10mg 10mM*1mL (in DMSO) |
是多酚醛,可渗透细胞,是一些脱氢酶(如乳酸脱氢酶、NAD-linked enzymes)的抑制剂。