Finasteride 非那雄胺/非那甾胺
| MDL | MFCD00869737 |
| EC | EINECS 620-534-3 |
| 别名 | 非那甾胺; Proscar |
| CAS | 98319-26-7 |
| 分子式 | C23H36N2O2 |
| 分子量 | 372.54 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| SMILES | O=C([C@H]1CC[C@]2([H])[C@]1(C)CC[C@]3([H])[C@@]4(C)C=CC(N[C@]4([H])CC[C@]32[H])=O)NC(C)(C)C |
| 靶点 | 5 alpha Reductase |
| 规格 | 10mg 10mM*1mL (in DMSO) 50mg |
Finasteride是睾酮5α-还原酶抑制剂。
使用本产品的应用案例（仅供参考）
In Vitro
Cell （dermal papilla cell(DPC), 10−5 M finasteride，48h）
DPCs (1.0 × 105 cells/ml in 100-mm dishes) were seeded into 100-mm culture dishes. After a night of adherent growth, DPCs were treated with 10−7 M DHT and 10−5 M finasteride (Jinpan, Beijing, China) for the next 48 h, respectively. The media were changed every 24 h. After 2 days of conditioned culture, DPCs were collected for the extraction of total RNA and protein.
来源文献：Zhang R, Li Y, Jia K, Xu X, Li Y, Zhao Y, Zhang X, Zhang J, Liu G, Deng S, Lian Z. Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep. Cell Death Dis. 2020 May 29;11(5):407. doi: 10.1038/s41419-020-2622-x. PMID: 32472005; PMCID: PMC7260202.