Adenosine 腺苷
| MDL | MFCD00005752 |
| EC | EINECS 200-389-9 |
| 别名 | 腺素苷; ?腺嘌呤核苷 |
| CAS | 58-61-7 |
| 分子式 | C10H13N5O4 |
| 分子量 | 267.24 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation[1-2]. |
| In Vitro | Adenosine (Adenine riboside) acts on four G-protein coupled receptors: two of them, A1 and A3, are primarily coupled to Gi family G proteins; and two of them, A2A and A2B, are mostly coupled to Gs like G proteins. These receptors are antagonized by xanthines including caffeine. Via these receptors it affects many cells and organs, usually having a cytoprotective function[2].Adenosine is an extracellular signaling molecule that is generated from its precursor molecules 5’-adenosine triphosphate (ATP) and 5’-adenosine monophosphate (AMP)[3].Adenosine is a common metabolite of ATP, which exhibits cytotoxic effects at high concentrations.Adenosine (1.0-4.0 mM; 12-24 hours) inhibits cell viability and triggers ER stress in HepG2 cells.Adenosine induces apoptosis in a variety of cancer cells. Adenosine (2.0 mM; 12-24 hours) induces autophagy in HepG2 cells. In HepG2 cell lines, Adenosine -induced AMPK/mTOR pathway activation partially blocked ER stress and decreased apoptotic cell death[4]. |
| SMILES | NC1=C2C(N([C@H]3[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2)=NC=N1 |
| 靶点 | DNA/RNA Synthesis |
| 数据来源文献 | [1]. Fredholm BB. Adenosine, an endogenous distress signal, modulates tissue damage and repair. Cell Death Differ. 2007;14(7):1315-1323.
[2]. Borea PA, Gessi S, Merighi S, Vincenzi F, Varani K. Pharmacology of Adenosine Receptors: The State of the Art. Physiol Rev. 2018;98(3):1591-1625. [3]. Eltzschig HK. Adenosine: an old drug newly discovered. Anesthesiology. 2009;111(4):904-915. [4]. Zhou XT, et al. Inhibition of autophagy enhances adenosine induced apoptosis in human hepatoblastoma HepG2 cells. Oncol Rep. 2019;41(2):829-838. |
| 规格 | 10mg 50mg 10mM*1mL (in DMSO) |
腺苷是一种遍布人体细胞的内源性核苷，是用于合成三磷酸腺苷（ATP）、腺嘌呤、腺苷酸、阿糖腺苷的重要中间体。可直接进入心肌经磷酸化生成腺苷酸。
使用本产品的应用案例（仅供参考）
In Vivo
Rat（Adenosine 50mg/kg，口服，2次/天，3天）
Seventy rats were randomly divided into 7 groups (female and male in equal numbers for each group): control group(8, C), SCM model group (12, SCM), AI treated group (10, AI,200 mg kg−1), CY extract treated group (10, CY, 1630 mg kg−1),Ade treated group (10, Ade, 50 mg kg−1), Arb treated group (10,Arb, 50 mg kg−1) and All treated group (10, All, 50 mg kg−1).The SCM model was induced by subcutaneous injection of LPS at a dose of 10 mg kg−1. The drugs were orally administered twice a day for 3 days, respectively. The C and SCM groups were orally administered with the same volume of distilled water in the meantime. All rats were sacrificed after the detection of the cardiac function and the blood sample was obtained from the abdominal aorta.
来源文献：Zhou N , Zeng MN , Li K , Yang YY , Bai ZY , Zheng XK , Feng WS . An integrated metabolomic strategy for the characterization of the effects of Chinese yam and its three active components on septic cardiomyopathy. Food Funct. 2018 Sep 19;9(9):4989-4997. doi: 10.1039/c8fo00688a. PMID: 30187904.