Ademetionine S-腺苷-L-蛋氨酸
货号：
IA0080
品牌：
Jinpan
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产品简介
| MDL | MFCD00871208 |
| EC | EINECS 249-946-8 |
| 别名 | SAM |
| CAS | 29908-03-0 |
| 分子式 | C15H22N6O5S |
| 分子量 | 398.44 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Ademetionine (AdoMet, S-Adenosylmethionine, SAMe), also known as SAMe, is a specific form of the amino acid methionine known as S-adenosyl-methionine. It is essential for the formation of glutathione, a water-soluble peptide that helps the body fight free radicals.[1] |
| In Vitro | Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA[1]. |
| In Vivo | SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently (12.5, 25, 50, 100 and 200 mg/kg sc.) decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors, and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes[1]. |
| SMILES | O[C@@H]([C@H]([C@H](N1C=NC2=C1N=CN=C2N)O3)O)[C@H]3C[S+](CC[C@H](N)C([O-])=O)C |
| 数据来源文献 | [1] Bottiglieri T. Expert Opin Investig Drugs. 1997, 6(4):417-26. |
| 规格 | 50mg 10mM*1mL (in Water) 100mg |
S-腺苷-L-蛋氨酸是蛋氨酸的中间代谢产物。它参与的甲基化有助于细胞生长和修复，是体内100 多种不同的甲基转移酶催化反应的甲基供体，也是合成谷胱甘肽(GSH)的转硫过程和合成多胺的转氨丙基过程的前体分子，并且还与多种酶的活性相关，维持细胞膜中的磷脂-脂质层。它还有助于维持影响情绪的几种激素和神经递质的作用。