氯化乙酰胆碱
| MDL | MFCD00011698 |
| EC | EINECS 200-468-8 |
| 别名 | 氯化乙酰氧基三甲基乙铵; ?乙酰氯化胆碱 |
| 英文名称 | Acetylcholine Chloride |
| CAS | 60-31-1 |
| 分子式 | C7H16ClNO2 |
| 分子量 | 181.66 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | Acetylcholine是神经递质，能诱导钙离子通道开放。[1-5] |
| In Vitro | Acetylcholine chloride (ACh chloride; 10 μM) opens the calcium channel and the fluorescence value and intracellular free calcium will increase significantly when the medium is with high calcium, while these will decrease when the medium is without calcium in sweat gland epithelial cells[3]. |
| In Vivo | Acetylcholine chloride (ACh chloride; SC; 20 mg/kg; single dose) induces pronounced cholinergic stimulation and increase of mouse survival in experimental infection[4]. |
| SMILES | O=C(OCC[N+](C)(C)C)C.[Cl-] |
| 靶点 | Calcium Channel |
| 数据来源文献 | [1]. Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct; 3 (5) : 413-420.
[2]. A Young, et al. Diarrhoea of famine and malnutrition–investigations using a rat model. 2–Ileal hypersecretion induced by starvation. Gut. 1990 Feb; 31 (2) :162-9. [3]. Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug; 300 (7) :335-41. [4]. P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan; 150 (3) :340-2. [5]. Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017; 24 (4) :353-357. |
| 备注 | 以上数据均来自公开文献, Jinpan暂未进行独立验证, 仅供参考。These protocols are for reference only. Jinpan does not independently validate these methods. |
| 规格 | 500mg 10mM*1mL in Water 10mM*1mL in DMSO 1g |
是一种神经递质，作用于包括人类在内的许多生物的周围神经系统（PNS）和中枢神经系统（CNS）。