BX-517

BX-517

货号:
IB1930

品牌:
Jinpan

BX-517

暂无详情

BX-517

暂无详情
产品简介
有效期 2年
描述 是一种有效的,选择性的 PDK1 抑制剂。
CAS 850717-64-5
分子式 C15H14N4O2
分子量 282.3
储存条件 -20℃
纯度 ≥98%
外观(性状) Solid
单位
生物活性 BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM.[1]
IC50 6 nM (PDK1)[1]
In Vitro BX-517 blocks activation of Akt in tumor cells, is potent with IC50 of 0.1-1.0 μM[1]. BX-517 blocks AKT2 activation in cells with submicromolar potency. BX-517 is 100-fold selective or better against a panel of seven additional Ser/Thr and Tyr kinases[2].
SMILES NC(NC1=CC=C(NC(/C2=C(C)C3=CC=CN3)=O)C2=C1)=O
靶点 PDK-1
数据来源文献 [1]. Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: optimization of BX-517. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3819-25.

[2]. Islam I, et al. Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3814-8.

规格 5mg 10mg