阿加曲班
货号：
IA3420
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| 描述 | 是凝血酶选择性抑制剂。 |
| MDL | MFCD00866789 |
| 别名 | 阿各卓泮;阿戈托班 |
| 英文名称 | Argatroban |
| CAS | 74863-84-6 |
| 分子式 | C23H36N6O5S |
| 分子量 | 508.63 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | White Powder |
| 单位 | 瓶 |
| 生物活性 | Argatroban (MD-805) is a direct, selective thrombin inhibitor.[1] |
| In Vitro | Argatroban (MD-805) may have a complementary effect for preventing thrombus formation without aggravating bleeding tendency because of its monotarget specificity to thrombin. Administration (0.5 to 2 micrograms/kg/min) of Argatroban (MD-805) is a safe anticoagulant for left heart bypass in repairs of traumatic aortic rupture associated with multiple organ injuries[1]. Argatroban (MD-805), as compared with heparin, appears to enhance reperfusion with TPA in patients with AMI, particularly in those patients with delayed presentation. The incidences of major bleeding and adverse clinical outcome were lower in the patients receiving argatroban[2]. |
| SMILES | O=C([C@@H]1N(C([C@@H](NS(=O)(C2=CC=CC3=C2NCC(C)C3)=O)CCCNC(N)=N)=O)CC[C@@H](C)C1)O |
| 靶点 | Thrombin |
| 数据来源文献 | [1]. Kawada, T., et al., Argatroban, an attractive anticoagulant, for left heart bypass with centrifugal pump for repair of traumatic aortic rupture. Jpn J Thorac Cardiovasc Surg, 1999. 47(3): p. 104-9. [2]. Jang, I.K., et al., A multicenter, randomized study of argatroban versus heparin as adjunct to tissue plasminogen activator (TPA) in acute myocardial infarction: myocardial infarction with novastan and TPA (MINT) study. J Am Coll Cardiol, 1999. 33(7): p. 1879-85. |
| 规格 | 5mg 10mg |