新利司他
货号：
IC3870
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| MDL | MFCD09839697 |
| EC | EINECS 1308068-626-2 |
| 别名 | 西替利斯他 |
| 英文名称 | Cetilistat |
| CAS | 282526-98-1 |
| 分子式 | C25H39NO3 |
| 分子量 | 401.58 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off-white Powder |
| 单位 | 瓶 |
| 生物活性 | Cetilistat (ATL-962), an inhibitor of pancreatic lipase, acts as an effective anti-obesity agent. Cetilistat inhibits rat and human pancreatic lipase activity with IC50s of 54.8 nM, and 5.95 nM, respectively[1]. |
| IC50 | 54.8 nM (rat pancreatic lipase), 5.95 nM (human pancreatic lipase)[1] |
| In Vitro | Cetilistat inhibits rat pancreatic lipase activity with an IC50 of 54.8 nM. Also, Cetilistat inhibits human pancreatic lipase activity with an IC50 of 5.95 nM, which is 9.2 times more potent than for rat pancreatic lipase[1]. |
| In Vivo | Cetilistat (3, 10, 30, or 100 mg/kg) reduces intestinal fat absorption by inhibiting pancreatic lipase activity in male SD rats[1].Cetilistat (4.9, 14.9, or 50.7 mg/kg; mixed into powdered high-fat diet; once a day; for three weeks) shows anti-obesity and antihyperlipidemic effects on DIO F344 rats by reducing intestinal fat absorption[1]. |
| SMILES | CC1=CC=C(N=C(OCCCCCCCCCCCCCCCC)OC2=O)C2=C1 |
| 靶点 | pancreatic lipase |
| 数据来源文献 | [1]. Yamada Y, et al. Cetilistat (ATL-962), a novel pancreatic lipase inhibitor, ameliorates body weight gain and improves lipid profiles in rats. Horm Metab Res. 2008 Aug;40(8):539-43. |
| 规格 | 50mg 100mg 250mg |
是胰腺癌和胃肠道脂酶的抑制剂。