BI-78D3

BI-78D3

货号:
IB2400

品牌:
Jinpan

BI-78D3

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BI-78D3

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产品简介
有效期 2年
MDL MFCD01313575
英文名称 BI-78D3
CAS 883065-90-5
分子式 C13H9N5O5S2
分子量 379.37
储存条件 2-8℃
纯度 ≥98%
外观(性状) Solid
单位
生物活性 BI-78D3是一种竞争性的JNK抑制剂,IC50为280 nM,其选择性比对p38α高100倍,对mTOR和PI-3K没有活性。[1]
IC50 JNK: 280 nM [1]
In Vitro BI-78D3 在体外和细胞中剂量依赖性地抑制 JNK 底物的磷酸化。[1]
In Vivo 在动物研究中,BI-78D3 不仅能阻断 JNK 依赖的 Con A 诱导的肝损伤,还能恢复 2 型糖尿病小鼠模型的胰岛素敏感性[1]。
SMILES O=C1N(C2=CC=C(OCCO3)C3=C2)C(SC4=NC=C([N+]([O-])=O)S4)=NN1
靶点 JNK
动物实验 Liver Injury Model. ConA and BI-78D3 was injected i.v. at 10 mg/kg into 6 to 8 weeks old male BL/6 mice. For partial hepatectomy, mice were anesthetized with isofluorane and subjected to midventral laparotomy followed by removal of the left lateral and median lobes. Animals were killed, blood was collected by cardiac puncture, and livers were surgically removed. Serum was separated and analyzed for alanine-aminotranferase levels.[1]
数据来源文献 [1] Stebbins JL, et al. Proc Natl Acad Sci U S A. 2008, 105(43):16809-16813.
规格 5mg 10mg

是一种新颖,有效且具有竞争力的JNK抑制剂