橙皮油内酯
货号：
IA4440
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| MDL | MFCD00075948 |
| InChIKey | RSDDHGSKLOSQFK-RVDMUPIBSA-N |
| InChI | InChI=1S/C19H22O3/c1-14(2)5-4-6-15(3)11-12-21-17-9-7-16-8-10-19(20)22-18(16)13-17/h5,7-11,13H,4,6,12H2,1-3H3/b15-11+ |
| PubChem CID | 1550607 |
| 别名 | 葡萄内酯 |
| 英文名称 | Auraptene |
| CAS | 495-02-3 |
| 分子式 | C19H22O3 |
| 分子量 | 298.38 |
| 储存条件 | 2-8℃ |
| 纯度 | HPLC≥98% |
| 外观（性状） | Off-white to light yellow (Solid) |
| 单位 | 瓶 |
| 生物活性 | Auraptene is the most abundant naturally occurring geranyloxycoumarin. It is primarily isolated from plants in the Rutaceae family, many of which, like citrus fruits, are used as food in many countries. Auraptene is a biologically active secondary metabolite with valuable properties.[1] |
| In Vitro | In vitro assays showed that auraptene decreased, in a dose-dependent manner, the secretion of matrix metalloproteinase 2 as well as key inflammatory mediators, including interleukin-6 (IL-6), IL-8, and chemokine (C-C motif) ligand-5 secreted by Aggregatibacter actinomycetemcomitans lipopolysaccharide-stimulated oral epithelial cells. Using gingival fibroblasts, auraptene showed a significant (P<.05) wound healing effect by its capacity to increase cell migration.[1] |
| SMILES | O=C1C=CC2=CC=C(OC/C=C(C)/CC/C=C(C)/C)C=C2O1 |
| 靶点 | MMP，Interleukin Related |
| 数据来源文献 | [1]. La VD, et al. Anti-inflammatory and wound healing potential of citrus auraptene. J Med Food. 2013 Oct;16(10):961-4. |
| 规格 | 5mg 10mg 20mg |
Auraptene 降低基质金属蛋白酶 2 (MMP-2) 以及关键炎症 因子，如 IL-6，IL-8 和趋化因子 (C-C 基序) 配体-5 (CCL5）的分泌。