6H-05
货号：
IH1260
品牌：
Jinpan
暂无详情
产品简介
| 别名 | K-RASINHIBITOR;6H05TFA |
| 英文名称 | 6H-05 |
| CAS | 2061344-88-3 |
| 分子式 | C22H31ClF3N3O4S3 |
| 分子量 | 590.14 |
| 储存条件 | 2~8度 |
| 纯度 | ≥98% |
| 单位 | 瓶 |
| 生物活性 | 6H05是一个致癌K-Ras(G12C)的选择性、变构抑制剂。6H05能够用作合成其它致癌性K-Ras(G12C)抑制剂的中间体。[1-2] |
| In Vitro | K-Ras G12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. |
| SMILES | O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F |
| 靶点 | Rho inhibitor;K-Ras |
| 数据来源文献 | [1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85. |
| 规格 | 2mg 5mg |
6H-05是一个K-Ras(G12C)的选择性、变构抑制剂。