西多福韦

西多福韦

货号:
IC1970

品牌:
Jinpan

西多福韦

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西多福韦

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产品简介
含量 Purity≥98%
MDL MFCD00866936
EC EINECS 638-807-0
别名 (S)-[[2-(4-氨基-2-氧-1(2H)嘧啶基)-1-(羟基甲基)乙氧基]甲基]膦酸;培哚普利叔丁胺盐
CAS 113852-37-2
分子式 C8H14N3O6P
分子量 279.19
纯度 ≥98%
单位
In Vitro Cidofovir处理培养的细胞,抑制人类巨细胞病毒(HCMV)感染。Cidofovir抑制巨细胞病毒(CMV)蚀斑形成,即使是感染后48小时后加入到细胞中,作用于Davis和AD-169株时IC50分别为0.9 μg/mL和1.6 μg/mL。[1] Cidofovir也抑制单纯疱疹病毒感染。此外,Cidofovir作用于猴肾细胞,抑制HSV-1诱导的细胞融合,也抑制HSV-1特异性蛋白的表达和病毒DNA的合成。[3]
In Vivo Cidofovir 每天按5 mg/kg剂量皮下注射给药受感染的豚鼠,持续给药5天,显著降低血,脾,肺,和唾液腺中病毒传染力。Cidofovir处理受感染的动物,显著降低淋巴细胞增多和脾脏的平均组织指数。[2] Cidofovir作用于皮内感染与HSV-1或HSV-2的无毛小鼠,抑制所有临床表现(皮肤损伤,后腿瘫痪,和死亡)。Cidofovir最显著的特点是感染后到直至第4天才单独给药,也显著抗HSV-1或HSV-2感染。[4] Cidofovir作用于皮下移植小鼠黑色素瘤B16细胞的C57B16/J小鼠,抑制产生的高度侵袭性的黑色素瘤的生长。[5]
SMILES OC[C@@H](OCP(O)(O)=O)CN1C=CC(N)=NC1=O
靶点 DNA/RNA Synthesis inhibitor
动物实验 Mice were treated daily with systemic cidofovir at several doses. In treated and control groups, tumour growth was measured using a calliper, and histological studies were performed.In untreated mice, massive invasive melanoma tumours were observed on day 5 after tumour cell grafting. Cidofovir treatment gave a dose-dependent reduction in tumour size. Tumour growth was inhibited by 62% at a dose of 37.5 mg kg(-1) three times weekly, as compared with control mice treated with saline alone. At 67 mg kg(-1) three times weekly, tumour growth was inhibited by 90%. Increasing the cidofovir dose to 50 or 100 mg kg(-1) daily resulted in a gradual increase in the antitumoral effect of the compound. In one experiment, cidofovir was administered at 100 mg kg(-1) five times weekly from the eighth day after the injection of tumour cells, when the tumour already had a volume of approximately 100 mm(3). In the treatment group, on the 14th day the tumour volume was approximately 200 mm(3), while in the control group it had increased to 750 mm(3).[5]
数据来源文献 [1] Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
[2] Li SB, et al. Antiviral Res, 1990, 13(5), 237-252.
[3] Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192.
[4] De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706.
[5] Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748.
规格 10mg 50mg

Cidofovir可通过抑制病毒DNA聚合酶活性以控制巨细胞病毒CMV复制。