蒿乙醚
货号：
IA1610
品牌：
Jinpan
暂无详情
产品简介
| MDL | MFCD00869355 |
| 别名 | (+)-Arteether,Artemotil |
| 英文名称 | β-Arteether |
| CAS | 75887-54-6 |
| 分子式 | C17H28O5 |
| 分子量 | 312.4 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | Artemotil (β-Arteether) has antimalarial activity for the treatment of chloroquine-resistant Plasmodium falciparum malaria with an IC50 of 1.61 nM. Artemotil also has central nervous system (CNS) neurotoxicity and anorectic toxicity in rats, dogs and monkeys[1-2]. |
| IC50 | 1.61 nM (Plasmodium falciparum malaria)[1] |
| In Vitro | The antimalarial activity of Artemotil is test in vitro against chloroquine-resistant and chloroquine-sensitive Plasmodium falciparum parasites. The mean 50% inhibitory concentration (IC50) for Artemotil is 1.61 nM (range 1.57-1.92 nM). Artemotil is approximately 2.5-fold more potent than artemisinin[1]. |
| In Vivo | Artemotil treatment (25 mg/kg; intravenous injection; daily; for 7 days; Sprague-Dawley male rats) shows anorectic toxicity and causes significant reductions in food consumption and body weight after day 2. AUC on day 7 is 5-fold higher than AUC on day 1. The elimination t1/2 of Artemotil is also prolonged from 13.7 hours (day 1) to 31.2 hours (day 7)[2]. |
| 货期 | 1-2天 |
| SMILES | C[C@@H]1[C@@](CC[C@@H](C)[C@]2([H])CC[C@]3(C)O4)([H])[C@@]2(OO3)[C@]4([H])O[C@@H]1OCC |
| 靶点 | Parasite |
| 数据来源文献 | [1]. Shmuklarsky MJ, et al. Comparison of beta-artemether and beta-arteether against malaria parasites in vitro and in vivo. Am J Trop Med Hyg. 1993 Mar;48(3):377-84. [2]. Li QG, et al. Arteether toxicokinetics and pharmacokinetics in rats after 25 mg/kg/day single and multiple doses. Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):213-23. |
| 规格 | 5mg 10mg 20mg |
是青蒿素的半合成类似物