Didymin；香蜂草苷
| MDL | MFCD00151177 |
| EC | EINECS 238-139-6 |
| 别名 | Iso-sakuranetin-7-putinoside;Neoponcirin |
| 英文名称 | Didymin |
| CAS | 14259-47-3 |
| 分子式 | C28H34O14 |
| 分子量 | 594.56 |
| 纯度 | HPLC≥98% |
| 单位 | 支 |
| SMILES | O=C1C[C@@H](C2=CC=C(OC)C=C2)OC3=CC(O[C@H]4[C@@H]([C@H]([C@@H]([C@@H](CO[C@H]5[C@@H]([C@@H]([C@H]([C@H](C)O5)O)O)O)O4)O)O)O)=CC(O)=C13 |
| 靶点 | Apoptosis |
| 规格 | 5mg 10mg 20mg |
Didymin具有抗氧化特性。通过抑制 N-Myc 和上调 RKIP 诱导凋亡。 据报道，Didymin在急性肝损伤、高血糖诱导的内皮功能障碍和死亡后具有抗炎活性。
使用本产品的应用案例（仅供参考）
In Vivo
Mice（372 C57BL/6 mice (male, weight about 25 g) ）, 腹腔注射，0.5, 1.5, 4.5 mg/kg
Three doses of Didymin (0.5, 1.5, 4.5 mg/kg, Jinpan, China) were administered intraperitoneally at 1 h after ICH insult. Mice were randomly divided into 5 groups: sham, ICH+vehicle (DMSO), ICH+Didymin (0.5 mg/kg), ICH+Didymin (1.5 mg/kg), and ICH+Didymin (4.5 mg/kg). Neurological test, brain water content, and Evans blue (EB) extravasation were evaluated at 24 h after ICH.
来源文献：Gu L, Sun M, Li R, Zhang X, Tao Y, Yuan Y, Luo X, Xie Z. Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage. Front Immunol. 2022 Jan 27;13:810582. doi: 10.3389/fimmu.2022.810582. PMID: 35154128; PMCID: PMC8828494.