Bisdemethoxycurcumin；双去甲氧基姜黄素
货号：
IB0560
品牌：
Jinpan
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产品简介
| EC | EINECS 1312995-182-4 |
| MDL | MFCD03419284 |
| 别名 | 姜黄素III |
| 英文名称 | Bisdemethoxycurcumin |
| CAS | 33171-05-0 |
| 分子式 | C19H16O4 |
| 分子量 | 308.33 |
| 纯度 | HPLC≥98% |
| 单位 | 支 |
| 生物活性 | Bisdemethoxycurcumin (BDMC)是一种天然纯在的姜黄素去甲氧基衍生物，具有多种生物活性，如消炎和抗癌活性。[1-2] |
| In Vitro | Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin, which is a natural substance found in the turmeric root. BDMC inhibits the growth of gastric cancer SGC 7901 cells in a dose?dependent manner. BDMC arrests the cell growth in G1 phase and thus, cells could not reach S phase and complete the cycle[2]. |
| In Vivo | BDMC may promote apoptosis in tumors via mitochondrial modulation. BDMC inhibits the tumor growth and caused an increase in body weight of gastric adenoadenocarcinoma xenograft model[2]. |
| SMILES | O=C(CC(/C=C/C1=CC=C(O)C=C1)=O)/C=C/C2=CC=C(O)C=C2.[E].[E] |
| 靶点 | Apoptosis |
| 动物实验 | Animal Models: human gastric adenoadenocarcinoma xenograft model (nude mice); Dosages: 100 mg/kg/day; Administration: s.c.[2] |
| 细胞实验 | The cells are grown at 37?C in a humidified atmosphere of 5% CO2. To evaluate the hypomethylation effect of bisdemethoxycurcumin, DAC is used as positive control. Curcumin, DMC, BDMC and DAC are prepared as stock solutions (20 mM) in dimethyl sulfoxide (DMSO) and diluted in sterile-filtered media before use. Cells (1×105) are seeded into 6-well culture plates. After 24 h of culture, the cells are treated with curcumin, DMC, BDMC (0-100 μM) or DAC (20 μM) for 72 h.[1] |
| 数据来源文献 | [1] Liu YL, et al. Mol Med Rep. 2011, 4(4):675-9. [2] Luo C, et al. Oncol Lett. 2015, 9(1):270-274. |
| 规格 | 10mg 10mM*1mL in DMSO 20mg |
是姜黄素衍生物，具有抗炎症和抗癌活性。