L-5-Hydroxytryptophan；L-5-羟基色氨酸
货号：
IH0400
品牌：
Jinpan
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产品简介
| EC | EINECS 224-411-1 |
| MDL | MFCD00064341 |
| 别名 | 5-羟基-L-色氨酸;5-羟色胺酸 |
| 英文名称 | L-5-Hydroxytryptophan |
| CAS | 4350-09-8 |
| 分子式 | C11H12N2O3 |
| 分子量 | 220.22 |
| 纯度 | HPLC≥98% |
| 单位 | 瓶 |
| 生物活性 | 5-Hydroxytryptophan (5-HTP, L-oxitriptan), also known as oxitriptan, is a naturally occurring amino acid and chemical precursor as well as a metabolic intermediate in the biosynthesis of the neurotransmitter serotonin.[1-2] |
| In Vitro | 5-Hydroxytryptophan (5-HTP) is a 5-HT precursor. In Caco-2 cells, exogenous 5-HTP, which can enter the cells, increases the density of microvilli[1]. |
| In Vivo | Systemic application of 5-HTP increases the density of microvilli in the mouse intestine in vivo[1] and allows frontal cortical serotonin response to stress in hyperphenylalaninaemic mice[2]. |
| SMILES | N[C@@H](CC1=CNC2=CC=C(O)C=C12)C(O)=O |
| 细胞实验 | Animal Models: The homozygote (–/–) PahEnu2 (ENU2) and homozygote (+/+) PahEnu2 [wild type (WT)] mice; Dosages: 2.5, 5, 10, 20 mg/kg;i.p.[2] |
| 数据来源文献 | [1] Nakamura K, et al. Int J Tryptophan Res. 2009, 2:37-43. [2] Pascucci T, et al. Int J Neuropsychopharmacol. 2009, 12(8):1 |
| 规格 | 100mg 10mM*1mL in DMSO 200mg |
L-5-Hydroxytryptophan (L-5-HTP) 是一种天然氨基酸和膳食补充剂，神经递质血清素的前体，以及reserpine 的拮抗剂。