LY2444296CAS号: 1346133-11-6分子式: C24H22F2N2O2分子量: 408.44描述纯度储存/保存方法靶点In vivo(体内研究)
产品描述 | |
描述 |
LY2444296 is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
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纯度 |
98%
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储存/保存方法 |
Store at -20℃ for one year(Powder);Store at 2-4℃ for two weeks;Store at -20℃ for six months after dissolution.
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生物活性 | |
靶点 |
KOPR(ki):ki: ~1 nM
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In vivo(体内研究) |
LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naïve adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593[2].
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