AZD-9291CAS号： 1421373-65-0分子式： C28H33N7O2分子量： 499.61描述纯度储存/保存方法别名外观可溶性/溶解性靶点In vitro(体外研究)In vivo(体内研究)
| 产品描述 | |
| 描述 |
AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM). |
| 纯度 |
>98%
|
| 储存/保存方法 |
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
|
| 基本信息 | |
| 别名 |
EGFR inhibitor; AZD9291; AZD 9291;Tagrisso;Osimertinib; Mereletinib
|
| 外观 |
Powder
|
| 可溶性/溶解性 |
DMSO ：99 mg/mL warmed (198.15 mM)
Ethanol ：43 mg/mL warmed (86.06 mM) |
| 生物活性 | |
| 靶点 |
L858R/T790M EGFR ,Exon 19 deletion EGFR ,WT EGFR
|
| In vitro(体外研究) |
AZD9291 shows significantly more potent inhibition of proliferation in mutant EGFR cell lines compared to wild-type in vitro.
|
| In vivo(体内研究) |
AZD9291(5mg/kg p.o.) causes profound regression of tumors across EGFRm+ (PC9) and EGFRm+/T790M (H1975) tumor models with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK in vivo.
|
分子结构图
