Ly 379268CAS号： 191471-52-0分子式： C7H9NO5分子量： 187.15描述应用储存/保存方法形态密度熔点沸点折射率IC50PK值Ki 数据可溶性/溶解性PubChem CID
| 产品描述 | |
| 描述 |
LY 379268 has been shown to act as a highly selective group II mGluR agonist with EC50 values of 2.69 and 4.48 nM for mGluR-2 (hmGluR-2) and mGluR-3 (hmGluR-3) respectively. LY 379268 has been shown to display > 80-fold selectivity over group I and group III receptors.
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| 应用 |
A highly selective group II mGlu receptor agonist
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| 储存/保存方法 |
Store at 4° C
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| 形态 |
Solid
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| 基本信息 | |
| 密度 |
~1.72 g/cm3 (Predicted)
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| 熔点 |
291.68° C (Predicted)
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| 沸点 |
~413.93° C at 760 mmHg (Predicted)
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| 折射率 |
n20D 1.62 (Predicted)
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| IC50 |
hmGlu2: EC5050 = 2.69 nM; hmGlu3 : EC5050 = 4.48 nM; Glutamate receptor ionotropic, kainate: IC50 = >100 µM (rat); Glutamate receptor ionotropic, AMPA: IC50 = >100 µM (rat)
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| PK值 |
pKa: 1.82 (Predicted), pKb: 8.94 (Predicted)
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| Ki 数据 |
mGluR-3: Ki= 5.8 nM (human); mGluR-2: Ki= 14.1 nM (human)
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| 可溶性/溶解性 |
Soluble in water (20 mM), and 1eq. NaOH (100 mM).
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| PubChem CID |
10197984
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