sting激动剂及相关产品推荐

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sting激动剂及相关产品推荐

STING分子在最初发现时只被认为是CDS信号通路中的一个普通接头蛋白，进一步研究表明它是环二核苷酸cyclic dinucleotide(CDNs)的直接感受分子。CDNs是细菌合成的重要第二信使，调节原核生物及哺乳动物的众多生物进程，能启动宿主天然免疫反应。CDNs和山酮衍生物xanthenone derivative(例如DMXAA)，可结合并活化STING，通过TBK1-IRF3依赖的信号通路来诱导I型干扰素表达。

相关产品推荐：

PRODUCT

ORIGIN/DESCRIPTION

GRADE*

WORKING

CONCENTRATION

QTY

CATALOG

CODE

STING Agonists

2’2’-cGAMP

2’5’-2’5’ Cyclic GMP-AMP

TLR2 -/ TLR4 –

100 ng – 100 µg/ml

500 µg

1 mg

tlrl-nacga22

tlrl-nacga22-1

2’3’-cGAMP

2’5’-3’5’ Cyclic GMP-AMP

TLR2 -/ TLR4 –

100 ng – 100 µg/ml

200 µg

500 µg

1 mg

5 mg

tlrl-ncga23-02 tlrl-nacga23

tlrl-nacga23-1

tlrl-nacga23-5

2’3’-cGAMP Control

Linear dinucleotide analog of 2’3’-cGAMP

TLR2 -/ TLR4 –

100 ng – 100 µg/ml

1 mg

tlrl-nagpap

2’3’-cGAMP VacciGrade™  

Preclinical grade 2’5’-3’5’ cyclic GMP-AMP

VacciGrade™

5 – 50 µg/mouse

1 mg

vac-nacga23

2’3’-cGAM(PS)2 (Rp/Sp)

Bis-phosphorothioate analog of 2’3’-cGAMP

TLR2 -/ TLR4 –

100 ng – 100 µg/ml

250 µg

tlrl-nacga2srs

2’3’-c-di-AMP

Synthetic analog of  c-di-AMP

TLR2 -/ TLR4 –

1 – 100 µg/ml

500 µg

tlrl-nacda23

2’3’-c-di-AM(PS)2 (Rp,Rp)

Bisphosphorothioate analog of 2’3’-c-di-AMP

TLR2 -/ TLR4 –

0.1-10 µg/ml

100 µg

500 µg

tlrl-nada2r-01

tlrl-nacda2r

2’3’-c-di-AM(PS)2 (Rp,Rp) VacciGrade™

Preclinical grade of bisphosphorothioate analog of
2’3’-c-di-AMP

VacciGrade™

5-50 µg/mouse

500 µg

vac-nacda2r

2’3’-c-di-GMP

Synthetic analog of c-di-GMP

TLR2 -/ TLR4 –

1 – 100 µg/ml

500 µg

tlrl-nacdg23

3’3’-cGAMP

3’5’-3’5’ Cyclic GMP-AMP

TLR2 -/ TLR4 –

100 ng – 100 µg/ml

500 µg

1 mg

5 x 0.5 mg

tlrl-nacga

tlrl-nacga-1

tlrl-nacga-2.5

3’3’-cGAMP Control

Linear dinucleotide analog of 3’3’-cGAMP

TLR2 -/ TLR4 –

100 ng – 100 µg/ml

1 mg

tlrl-nagpap

3’3’-cGAMP Fluorinated

Difluor cyclic [G(3’,5’)pA(3’,5’)p]

TLR2 -/ TLR4 –

100 ng – 10 µg/ml

100 µg

tlrl-nacgaf

cAIMP (CL592)

Cyclic [A(3’,5’)pI(3’,5’)p]

TLR2 -/ TLR4 –

300 ng – 30 µg/ml

500 µg

tlrl-nacai

cAIMP Difluor (CL614)

Difluor cyclic [A(3’,5’)pI(3’,5’)p]

TLR2 -/ TLR4 –

100 ng – 30 µg/ml

250 µg

tlrl-nacaidf

cAIM(PS)2 Difluor (Rp/Sp)

Difluor and bisphosphorothioate analog of cAIMP

TLR2 -/ TLR4 –

100 ng – 30 µg/ml

100 µg

tlrl-nacairs

c-di-AMP

3’5’ Cyclic di-AMP

TLR2 -/ TLR4 –

1 – 100 µg/ml

1 mg

5 x 1 mg

tlrl-nacda

tlrl-nacda-5

c-di-AMP Control

Linear dinucleotide analog of c-di-AMP – pApA

TLR2 -/ TLR4 –

1 – 100 µg/ml

1 mg

tlrl-napapa

c-di-AMP VacciGrade™

Sterile 3’5’ cyclic di-AMP

VacciGrade™

5 – 50 µg/mouse

1 mg

vac-nacda

c-di-AMP Fluorinated

Difluoro [A(3’,5’)pA(3’,5’)p]

TLR2 -/ TLR4 –

300 ng – 30 µg/ml

100 µg

tlrl-nacdaf

c-di-GMP

3’5’ Cyclic di-GMP

TLR2 -/ TLR4 –

10 – 100 µg/ml

1 mg

5 x 1 mg

tlrl-nacdg

tlrl-nacdg-5

c-di-GMP Control

Linear dinucleotide 5’-pGpG; negative control for c-di-GMP

TLR2 -/ TLR4 –

10 – 100 µg/ml

1 mg

tlrl-napgpg

c-di-GMP VacciGrade™

Preclinical grade of cyclic [G(3’,5’)pG(3’,5’)p]

VacciGrade™

5 – 50 µg/mouse

1 mg

tlrl-nacdg

c-di-GMP Fluorinated

Difluoro cyclic [G(3’,5’)pG(3’,5’)p]

TLR2 -/ TLR4 –

3 – 100 µg/ml

100 µg

tlrl-nacdgf

c-di-IMP

Cyclic [I(3’,5’)pI(3’,5’)p]

TLR2 -/ TLR4 –

10 – 100 µg/ml

1 mg

tlrl-nacdi

c-di-UMP

Negative control for c-di-IMP

TLR2 -/ TLR4 –

1 – 100 µg/ml

1 mg

tlrl-nacdu

DMXAA

5,6-dimethyl-xanthenone-4-acetic acid

TLR2 -/ TLR4 –

10 – 100 µg/ml

5 mg

tlrl-dmx

如需购买或咨询以上产品详情，请联系Invivogen代理商-上海金畔生物