阿托伐醌
货号：
IA4670
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| 描述 | 具有抗寄生虫活性。 |
| MDL | MFCD00889188 |
| 别名 | 阿托喹酮 |
| 英文名称 | Atovaquone |
| CAS | 95233-18-4 |
| 分子式 | C22H19ClO3 |
| 分子量 | 366.84 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | Solid |
| 单位 | 瓶 |
| 生物活性 | Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1-2]. |
| IC50 | 460 nM (human cytochrome bc1); 2.0 nM (P. falciparum cytochrome bc1)[1] |
| In Vitro | Atovaquone targets to the Qo site of the Plasmodium cytochrome bc1 complex of the mitochondrial electron transport chain.Atovaquone is against the development in the mosquito from gamete production, through fertilization, zygote formation and finally, to the development of the mature ookinete, and demonstrates an IC50 of 67 nM providing further evidence of the transmission blocking potential of this molecule[1]. |
| In Vivo | Atovaquone (oral administration; 100 mg/kg; once daily) is against survival rates of mice, mice treated orally died within 22 days after discontinuation of sulfadiazine,while the control group died at day 14[2]. |
| SMILES | O=C1C([C@H]2CC[C@H](C3=CC=C(Cl)C=C3)CC2)=C(O)C(C4=C1C=CC=C4)=O |
| 靶点 | Parasite |
| 数据来源文献 | [1]. Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5(177):177ra37. [2]. Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45(6):1771-9. |
| 规格 | 5mg 10mg 25mg |