标签归档：阿托

阿托伐醌

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阿托伐醌

货号：
IA4670

品牌：
Jinpan

阿托伐醌

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产品简介
有效期 2年
描述 具有抗寄生虫活性。
MDL MFCD00889188
别名 阿托喹酮
英文名称 Atovaquone
CAS 95233-18-4
分子式 C22H19ClO3
分子量 366.84
储存条件 2-8℃
纯度 ≥98%
外观（性状） Solid
单位 瓶
生物活性 Atovaquone (Atavaquone) is a potent, selective and orally active inhibitor of the parasite’s mitochondrial cytochrome bc1 complex. Atovaquone is against human and P. falciparum cytochrome bc1 activity with IC50 values of 460 nM and 2.0 nM, respectively. Atovaquone is an antimalarial agent and has the potential for the investigation of neumocystis pneumonia, toxoplasmosis, malaria, and babesia[1-2].
IC50 460 nM (human cytochrome bc1); 2.0 nM (P. falciparum cytochrome bc1)[1]
In Vitro Atovaquone targets to the Qo site of the Plasmodium cytochrome bc1 complex of the mitochondrial electron transport chain.Atovaquone is against the development in the mosquito from gamete production, through fertilization, zygote formation and finally, to the development of the mature ookinete, and demonstrates an IC50 of 67 nM providing further evidence of the transmission blocking potential of this molecule[1].
In Vivo Atovaquone (oral administration; 100 mg/kg; once daily) is against survival rates of mice, mice treated orally died within 22 days after discontinuation of sulfadiazine,while the control group died at day 14[2].
SMILES O=C1C([C@H]2CC[C@H](C3=CC=C(Cl)C=C3)CC2)=C(O)C(C4=C1C=CC=C4)=O
靶点 Parasite
数据来源文献 [1]. Nilsen A, et al. Quinolone-3-diarylethers: a new class of antimalarial drug.Sci Transl Med. 2013 Mar 20;5(177):177ra37.
[2]. Schöler N, et al. Atovaquone nanosuspensions show excellent therapeutic effect in a new murine model of reactivated toxoplasmosis.Antimicrob Agents Chemother. 2001 Jun;45(6):1771-9.
规格 5mg 10mg 25mg

阿托伐他汀钙 标准品

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阿托伐他汀钙 标准品

货号：
SA5270

品牌：
Jinpan

阿托伐他汀钙 标准品

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产品简介
MDL MFCD09752074
别名 atorvastatin calcium trihydrate;阿托伐他汀钙水合物;
英文名称 Atorvastatin calcium
CAS 344423-98-9
分子式 2C33H34CaFN2O5·3H2O
分子量 1209.41
储存条件 2-8℃
纯度 HPLC≥98%
单位 瓶
SMILES O=C([O-])C[C@H](O)C[C@H](O)CCN1C(C2=CC=C(F)C=C2)=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C1C(C)C.O=C([O-])C[C@H](O)C[C@H](O)CCN5C(C6=CC=C(F)C=C6)=C(C7=CC=CC=C7)C(C(NC8=CC=CC=C8)=O)=C5C(C)C.[H]O[H].[H]O[H].[H]O[H].[Ca+2]
规格 100mg

阿托伐他汀钙三水

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阿托伐他汀钙三水

货号：
IA0580

品牌：
Jinpan

阿托伐他汀钙三水

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产品简介
MDL MFCD03613598
EC EINECS 200-659-6
别名 阿托伐他汀钙三水合物, 阿托伐他汀钙水合物, atorvastatin calcium trihydrate, Atorvastatin hemicalcium salt sesquihydrate, atorvastatin calcium trihydrate
英文名称 Atorvastatin Hemicalcium Salt Trihydrate
CAS 344423-98-9
分子式 2(C33H34FN2O5).Ca.3(H2O)
分子量 1209.4
纯度 HPLC≥98%
单位 瓶
SMILES FC1=CC=C(C2=C(C3=CC=CC=C3)C(C(NC4=CC=CC=C4)=O)=C(C(C)C)N2CC[C@@H](O)C[C@@H](O)CC([O-])=O)C=C1.[0.5Ca2+]
靶点 HMG-CoA Reductase (HMGCR)
规格 10mg 10mM*1mL (in DMSO) 50mg

Atorvastatin hemicalcium salt 是有效的 HMG-CoA 还原酶抑制剂。