比拉斯汀
货号：
IB1630
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| 描述 | 是组胺H1受体拮抗剂，可用于变应性鼻结膜炎和荨麻疹的相关研究。 |
| MDL | MFCD09837814 |
| 英文名称 | Bilastine |
| CAS | 202189-78-4 |
| 分子式 | C28H37N3O3 |
| 分子量 | 463.61 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to yellowish crystalline Powder |
| 单位 | 瓶 |
| 生物活性 | Bilastine是一种新型耐受的、无镇静作用的抗组胺剂，针对H1 receptor。[1] |
| In Vitro | Bilastine has a high specific affinity for the H1-receptor but it has no or very low affinity for 30 other tested receptors[1]. It is lack of significant antagonism against serotonin, bradykinin, leukotriene D4, calcium, muscarinic M3-receptors, α1-adrenoceptors, β2-adrenoceptors, and H2- and H3- receptors[2]. |
| In Vivo | Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms in patients with allergic rhinoconjunctivitis. Bilastine is well tolerated. In the fasting state bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice. In vivo studies in rats have demonstrated reduction in histamine-stimulated smooth muscular contraction, bronchospasms, endothelial permeability, and microvascular extravasation[1]. |
| SMILES | CC(C)(C1=CC=C(CCN2CCC(C3=NC4=CC=CC=C4N3CCOCC)CC2)C=C1)C(O)=O |
| 靶点 | Histamine Receptor |
| 数据来源文献 | [1] Ole D. Wolthers. BioMed Research International. 2013, 626837. [2] Corcóstegui R, et al. Drugs R D. 2005, 6(6):371-84. |
| 规格 | 5mg |