标签归档：斯汀

Acrivastine/BW825C；阿伐斯汀

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Acrivastine/BW825C；阿伐斯汀

货号：
IA2090

品牌：
Jinpan

Acrivastine/BW825C；阿伐斯汀

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产品简介
MDL MFCD00869830
别名 BW825C;阿伐司丁
英文名称 Acrivastine/BW825C
CAS 87848-99-5
分子式 C22H24N2O2
分子量 348.44
纯度 HPLC≥98%
单位 瓶
生物活性 Acrivastine (BW825C) is a short acting histamine 1 receptor antagonist for the treatment of allergic rhinitis.[1-2]
In Vivo Acrivastine (usually 8mg three times daily) is an effective and well tolerated antihistamine in the treatment of chronic urticaria and allergic rhinitis. Acrivastine is more effective than placebo and similar in efficacy to clemastine or terfenadine in the treatment of seasonal allergic rhinitis. In the treatment of dermatoses in which histamine has a pathogenetic role, the efficacy of acrivastine is superior to that of placebo and similar to that of usual dosages of clemastine, hydroxyzine, chlorpheniramine, cyproheptadine or terfenadine. Acrivastine causes less drowsiness than clemastine, the incidence of adverse effects being indistinguishable from that with placebo or terfenadine[1]. Both 4 mg and 8 mg acrivastine alleviate the symptoms of seasonal allergic rhinitis with significant improvements in the symptom scores for sneezing, running nose and the calculated overall score. In addition, 8 mg acrivastine reduces the symptom scores for watery eyes and itchy throat. Acrivastine is both well tolerated and effective in the treatment of seasonal allergic rhinitis[2].
SMILES O=C(O)/C=C/C1=NC(/C(C2=CC=C(C)C=C2)=C/CN3CCCC3)=CC=C1
靶点 Histamine Receptor
数据来源文献 [1]. Brogden RN, et al. Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders. Drugs. 1991 Jun;41(6):927-40.

[2]. Gibbs TG, et al. Acrivastine in two doses compared with placebo in a multicentre, parallel group study for the treatment of seasonal allergic rhinitis. Br J Clin Pract. 1989 Jan;43(1):11-4
规格 5mg 10mg 20mg

是histamine 1受体拮抗剂。

盐酸氮卓斯汀

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盐酸氮卓斯汀

货号：
IA2330

品牌：
Jinpan

盐酸氮卓斯汀

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产品简介
MDL MFCD00242783
EC EINECS 620-469-0
别名 4-(4-氯苄基)-2-(1-甲基氮杂卓-4-基)-1-酞嗪酮盐酸盐
英文名称 Azelastine Hydrochloride
CAS 79307-93-0
分子式 C22H24ClN3O.HCl
分子量 418.36
纯度 HPLC≥98%
单位 支
货期 1-2个工作日
SMILES O=C1N(C2CCN(C)CCC2)N=C(CC3=CC=C(Cl)C=C3)C4=C1C=CC=C4.Cl
靶点 Histamine Receptor
规格 100mg 200mg 500mg
Azelastine盐酸盐是H1受体拮抗剂。

比拉斯汀

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比拉斯汀

货号：
IB1630

品牌：
Jinpan

比拉斯汀

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比拉斯汀

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产品简介
有效期 2年
描述 是组胺H1受体拮抗剂，可用于变应性鼻结膜炎和荨麻疹的相关研究。
MDL MFCD09837814
英文名称 Bilastine
CAS 202189-78-4
分子式 C28H37N3O3
分子量 463.61
储存条件 2-8℃
纯度 ≥98%
外观（性状） White to yellowish crystalline Powder
单位 瓶
生物活性 Bilastine是一种新型耐受的、无镇静作用的抗组胺剂，针对H1 receptor。[1]
In Vitro Bilastine has a high specific affinity for the H1-receptor but it has no or very low affinity for 30 other tested receptors[1]. It is lack of significant antagonism against serotonin, bradykinin, leukotriene D4, calcium, muscarinic M3-receptors, α1-adrenoceptors, β2-adrenoceptors, and H2- and H3- receptors[2].
In Vivo Bilastine is efficacious in all nasal symptoms including obstruction and in eye symptoms in patients with allergic rhinoconjunctivitis. Bilastine is well tolerated. In the fasting state bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice. In vivo studies in rats have demonstrated reduction in histamine-stimulated smooth muscular contraction, bronchospasms, endothelial permeability, and microvascular extravasation[1].
SMILES CC(C)(C1=CC=C(CCN2CCC(C3=NC4=CC=CC=C4N3CCOCC)CC2)C=C1)C(O)=O
靶点 Histamine Receptor
数据来源文献 [1] Ole D. Wolthers. BioMed Research International. 2013, 626837.
[2] Corcóstegui R, et al. Drugs R D. 2005, 6(6):371-84.
规格 5mg