阿扎环醇

阿扎环醇

货号:
IA3570

品牌:
Jinpan

阿扎环醇

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产品简介
有效期 2年
描述 是一种中枢神经系统抑制剂,可用于减少精神病引起的幻觉的相关研究。
EC EINECS 204-092-5
MDL MFCD00066980
InChIKey ZMISODWVFHHWNR-UHFFFAOYSA-N
InChI InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2
PubChem CID 15723
别名 MER-17;MDL-4829;二苯基哌啶甲醇;α,α-二苯基-4-哌啶甲醇
英文名称 Azacyclonol
CAS 115-46-8
分子式 C18H21NO
分子量 267.37
储存条件 -20℃
纯度 ≥98%
外观(性状) White to light beige crystalline Powder
单位
生物活性 Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations[1-3].
In Vitro Azacyclonol is formed from Terfenadine in rat liver[2].
In Vivo Azacyclonol causes depressed activity in mice and rats[3].Azacyclonol antagonizes increased coordination activity in mice induced by pipradrol, amphetamine, morphine and cocaine and prolongs Hexobarbital hypnosis[3].
SMILES OC(C1=CC=CC=C1)(C2CCNCC2)C3=CC=CC=C3
靶点 Others
数据来源文献 [1]. Brown DA, et, al. The effects of some centrally acting drugs on ganglionic transmission in the cat.
[2]. Jurima-Romet M, et, al. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells. Cell Biol Toxicol. 1995 Dec;11(6):313-27.
[3]. BRAUN DL, et, al. The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. J Pharmacol Exp Ther. 1956 Oct;118(2):153-61.
规格 500mg 1g