阿扎环醇
货号：
IA3570
品牌：
Jinpan
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产品简介
| 有效期 | 2年 |
| 描述 | 是一种中枢神经系统抑制剂，可用于减少精神病引起的幻觉的相关研究。 |
| EC | EINECS 204-092-5 |
| MDL | MFCD00066980 |
| InChIKey | ZMISODWVFHHWNR-UHFFFAOYSA-N |
| InChI | InChI=1S/C18H21NO/c20-18(15-7-3-1-4-8-15,16-9-5-2-6-10-16)17-11-13-19-14-12-17/h1-10,17,19-20H,11-14H2 |
| PubChem CID | 15723 |
| 别名 | MER-17;MDL-4829;二苯基哌啶甲醇;α,α-二苯基-4-哌啶甲醇 |
| 英文名称 | Azacyclonol |
| CAS | 115-46-8 |
| 分子式 | C18H21NO |
| 分子量 | 267.37 |
| 储存条件 | -20℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to light beige crystalline Powder |
| 单位 | 瓶 |
| 生物活性 | Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations[1-3]. |
| In Vitro | Azacyclonol is formed from Terfenadine in rat liver[2]. |
| In Vivo | Azacyclonol causes depressed activity in mice and rats[3].Azacyclonol antagonizes increased coordination activity in mice induced by pipradrol, amphetamine, morphine and cocaine and prolongs Hexobarbital hypnosis[3]. |
| SMILES | OC(C1=CC=CC=C1)(C2CCNCC2)C3=CC=CC=C3 |
| 靶点 | Others |
| 数据来源文献 | [1]. Brown DA, et, al. The effects of some centrally acting drugs on ganglionic transmission in the cat. [2]. Jurima-Romet M, et, al. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells. Cell Biol Toxicol. 1995 Dec;11(6):313-27. [3]. BRAUN DL, et, al. The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. J Pharmacol Exp Ther. 1956 Oct;118(2):153-61. |
| 规格 | 500mg 1g |