Tirasemtiv

Tirasemtiv

货号:
IT2730

品牌:
Jinpan

Tirasemtiv

暂无详情
产品简介
有效期 2年
描述 是一种新型的快速骨骼肌钙蛋白小分子激活剂。
别名 CK-2017357
CAS 1005491-05-3
分子式 C12H14N4O
分子量 230.27
储存条件 -20℃
纯度 ≥98%
外观(性状) Solid
单位
生物活性 Tirasemtiv is a fast skeletal troponin activator that sensitizes the sarcomere to calcium; this mechanism of action amplifies the response of muscle to neuromuscular input producing greater force when nerve input is reduced. [1]
In Vivo A single dose of tirasemtiv significantly increases submaximal isometric force, forelimb grip strength, grid hang time, and rotarod performance in a female transgenic mouse model (B6SJL-SOD1 G93A) of ALS with functional deficits. Additionally, diaphragm force and tidal volume are significantly higher in tirasemtiv-treated female B6SJL-SOD1 G93A mice. [1]
SMILES O=C1N(C(CC)CC)C2=NC(C#C)=CN=C2N1
靶点 Others
数据来源文献 [1] Darren T Hwee, et al. PLoS One. 2014 May 7;9(5):e96921.
规格 1mg 5mg 10mg