匹克硫酸钠
货号：
IS2930
品牌：
Jinpan
暂无详情
产品简介
| 有效期 | 2年 |
| 描述 | Sodium Picosulfate可以抑制水和电解质类的吸收并增加它们的分泌，可用于泻药方向的相关研究。 |
| MDL | MFCD03427264 |
| EC | EINECS 233-120-9 |
| 别名 | 阿齐沙坦酯；苉可硫酸钠 |
| 英文名称 | Sodium Picosulfate |
| CAS | 10040-45-6 |
| 分子式 | C18H13NNa2O8S2 |
| 分子量 | 481.41 |
| 储存条件 | 2-8℃ |
| 纯度 | ≥98% |
| 外观（性状） | White to off-white Powder or Crystals |
| 单位 | 瓶 |
| 生物活性 | Sodium Picosulfate inhibits absorption of water and electrolytes, and increases their secretion [1]. |
| In Vivo | 10mg/kg/day Sodium Picosulphate pretreated for 23 weeks does not induce any significant change in the duration of long spike bursts (LSB) which are associated with phasic contractions, or in LSB frequency in the fasted state or after a 3-gram meal [2]. |
| SMILES | O=S(OC1=CC=C(C=C1)C(C2=CC=CC=N2)C3=CC=C(OS(=O)([O-])=O)C=C3)([O-])=O.[Na+].[Na+] |
| 靶点 | Others |
| 动物实验 | The effect of sodium picosulfate was examined in liver cell cultures of rabbit, rat and man exposed to substance concentrations of 25, 50, 100, 200, 400, 800 and 1600 micrograms/ml. At 400, 800 and 1600 micrograms/ml the rapidly growing cultured liver cells of rabbit showed dose-dependently vacuolic and fatty change as well as necrosis combined with a lowered mitotic activity and a slight increase in LDH values in the medium at 800 and 1600 micrograms/ml. Comparable but less severe effects were observed in 4-day old liver cell cultures of rat, while liver cells cultured for 6 to 11 days tolerated 1600 micrograms/ml sodium picosulfate. In human liver cultures the number of cells was slightly lowered at 800 and 1600 micrograms/ml and the number of nuclei in division was decreased dependent on dose.[1] |
| 细胞实验 | Ceco-colonic myoelectrical activity was investigated in rats pretreated for 23 weeks by sennosides (10 or 40 mg/kg/day), Na-picosulfate (2.5 or 10 mg/kg/day) or laxative vehicle (control). On the last week of treatment the animals were equipped with Nichrome electrodes on the cecum, the proximal and distal colon. In comparison with controls, sennoside or Na-picosulfate treatment did not induce any significant (p > 0.05) change in the duration of long spike bursts (LSB) which are associated with phasic contractions. On the last 2 days of treatment the frequency of LSB for 2 h before and 2 h after laxative administration, as well as for 30 min after a 3-gram meal was not significantly (p > 0.05) different in control and treated animals. Similarly, on the first 2 days, as well as on days 13 and 14, after the end of treatment, no significant (p > 0.05) difference in the LSB frequency appeared between control and treated animals, in the fasted state or after a 3-gram meal.[2] |
| 数据来源文献 | [1]. Nishikawa, J. and A. Kast, Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man. Arzneimittelforschung, 1981. 31(2): p. 321-5. [2]. Fioramonti, J., C. Dupuy, and L. Bueno, In vivo motility of rat colon chronically pretreated with sennosides. Pharmacology, 1993. 47 Suppl 1: p. 155-61. |
| 规格 | 10mg 50mg 100mg |