Alda-1
货号:
IA4570
品牌:
Jinpan
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产品简介
有效期 | 2年 |
InChIKey | NMKJFZCBCIUYHI-UHFFFAOYSA-N |
InChI | InChI=1S/C15H11Cl2NO3/c16-10-2-1-3-11(17)14(10)15(19)18-7-9-4-5-12-13(6-9)21-8-20-12/h1-6H,7-8H2,(H,18,19) |
PubChem CID | 831629 |
英文名称 | Alda-1 |
CAS | 349438-38-6 |
分子式 | C15H11Cl2NO3 |
分子量 | 324.16 |
储存条件 | 2-8℃ |
纯度 | ≥98% |
外观(性状) | White to off-white Powder |
单位 | 瓶 |
生物活性 | Alda-1 is an ALDH2 agonist, a cell-permeable activator of both the wild-type ALDH2*1 and the Asian E487K mutant ALDH2*2 forms of mitochondrial aldehyde dehydrogenase 2 (mtALDH2).[1-2] |
In Vitro | Alda-1 alleviated liver injury after hepatic I/R. Pretreatment with Alda-1 significantly alleviated I/R-induced elevations of alanine aminotransferase and aspartate aminotransferase, and significantly blunted the pathological injury of the liver. Moreover, Alda-1 significantly inhibited ROS and proinflammatory cytokines production, 4-HNE and MDA accumulation, and apoptosis. Increased ALDH2 activity was found after Alda-1 administration. No significant changes in ALDH2 expression were observed after I/R[2]. |
SMILES | O=C(NCC1=CC=C(OCO2)C2=C1)C3=C(Cl)C=CC=C3Cl |
靶点 | Aldehyde Dehydrogenase (ALDH) |
动物实验 | The H/R (Hypoxia/reoxygenation) group cells are incubated under a hypoxic atmosphere (95% N2+5% CO2) for 6 h followed by 120 min reoxygenation (95% air + 5% CO2). The control incubation is normoxic conditions (95% air + 5% CO2) for the entire experiment. In the H/R+Alda-1 group, cells are incubated with Alda-1 (20 μM) for 60 min at 37℃ (95% air/5% CO2) before exposure to hypoxia. Furthermore, BRL-3A cells are treated with 5 μM 4-HNE for 60min before exposure to hypoxia to estimate whether 4-HNE could affect H/R.[2] |
细胞实验 | Animal Models: Male Sprague-Dawley rats (IR model); Dosages: 10 mg/kg; Administration: i.p.[2] |
数据来源文献 | [1] Samantha Perez-Miller, et al. Nat Struct Mol Biol. 2010, 17(2): 159-164. [2] Zhang T, et al. Free Radic Res. 2018, 52(6):629-638. |
规格 | 5mg 10mg |
是一种ALDH2激动剂。